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TActProjectYearSubPrincipal Investigator(s)/ Project Leader(s)OrganizationFiscal YearAdmin ICFunding ICFY Total Cost by ICSimilar Projects
Opioid Antagonists with Morphine for Neuropathic Pain
1TfR41ActfNS047807Projectf01Yearf
BURNS, LINDSAY Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2004NINDS
NINDS
$100,000
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Food Effect study and drug supply scale-up for PTI-125
1TfR01ActfAG067972Projectf01A1Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2021NIA
NIA
$2,710,220
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IND- and NDA-enabling toxicology studies for PTI-125, a novel small molecule for Alzheimer's disease
1TfR44ActfAG050301Projectf01Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2015NIA
NIA
$225,000
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Extending clinical trial in AD patients from 1 to 3 months
3TfR44ActfAG060878Projectf01S1Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2018NIA
NIA
$374,500
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Multiple Ascending Dose clinical trial of PTI-125, a novel AD therapeutic candidate
1TfR44ActfAG060878Projectf01Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2018NIA
NIA
$260,585
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Additional bioanalytical, dose analysis and DSMB costs for PTI-125 development
3TfR44ActfAG056166Projectf02S1Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2017NIA
NIA
$141,748
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Increasing size of Phase 2b clinical trial to 60 patients
3TfR44ActfAG060878Projectf02S1Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2020NIA
NIA
$374,500
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IND- and NDA-enabling toxicology studies for PTI-125, a novel small molecule for Alzheimer's disease
4TfR44ActfAG050301Projectf02Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2016NIA
NIA
$1,500,000
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IND, FIH study and 3-month tox for PTI-125, a novel therapeutic for Alzheimer's disease
4TfR44ActfAG056166Projectf02Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2017NIA
NIA
$1,500,000
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Open-label extension of a 3-month blinded clinical trial of PTI-125
1TfR44ActfAG065152Projectf01Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2020NIA
NIA
$2,499,896
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Multiple Ascending Dose clinical trial of PTI-125, a novel AD therapeutic candidate
4TfR44ActfAG060878Projectf02Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2019NIA
NIA
$2,896,561
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IND, FIH study and 3-month tox for PTI-125, a novel therapeutic for Alzheimer's disease
1TfR44ActfAG056166Projectf01Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2017NIA
NIA
$225,000
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Solid oral dosage form and chronic tox for PTI-125
2TfR44ActfAG056166Projectf03Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2018NIA
NIA
$2,896,320
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Additional costs related to formulation, chronic tox and general development of PTI-125
3TfR44ActfAG056166Projectf03S1Yearf
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2018NIA
NIA
$350,000
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Preformulation and formulation development of Fenrock, an Abuse-resistant Fentanyl Transdermal Patch
1TfR44ActfDA042639Projectf01A1Yearf
KUCERA, SHAWN Principal Investigator(s)/ Project Leader(s)
ZAMLOOT, MICHAEL SAMUEL Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2017NIDA
NIDA
$349,947
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Preformulation and formulation development of Fenrock, an Abuse-resistant Fentanyl Transdermal Patch
4TfR44ActfDA042639Projectf02Yearf
KUCERA, SHAWN Principal Investigator(s)/ Project Leader(s)
ZAMLOOT, MICHAEL SAMUEL Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2019NIDA
NIDA
$1,879,039
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Development of PTI-125-DX, a blood-based diagnostic for Alzheimer's disease
5TfR44ActfAG057329Projectf03Yearf
THORNTON, GEORGE BEN Principal Investigator(s)/ Project Leader(s)
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
WANG, HOAU-YAN Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2020NIA
NIA
$450,142
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Development of PTI-125-DX, a blood-based diagnostic for Alzheimer's disease
4TfR44ActfAG057329Projectf02Yearf
THORNTON, GEORGE BEN Principal Investigator(s)/ Project Leader(s)
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
WANG, HOAU-YAN Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2019NIA
NIA
$1,109,748
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Development of PTI-125-DX, a blood-based diagnostic for Alzheimer's disease
1TfR42ActfAG057329Projectf01Yearf
THORNTON, GEORGE BEN Principal Investigator(s)/ Project Leader(s)
BURNS, LINDSAY H Principal Investigator(s)/ Project Leader(s)
WANG, HOAU-YAN Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2017NIA
NIA
$295,343
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Abuse-deterrent sustained-release hydromorphone
1TfR43ActfDA019739Projectf01A1Yearf
ZAMLOOT, MICHAEL SAMUEL Principal Investigator(s)/ Project Leader(s)
CASSAVA SCIENCES, INC2006NIDA
NIDA
$100,000
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