ABSTRACT Schizophrenia (SZ) is characterized by a severe and debilitating loss of social functioning. Despite considerable efforts to find ways to improve social functioning, little satisfactory progress has been made. The typical age of onset for SZ (i.e., late adolescence / early adulthood) coincides with a period of critical psychosocial development, during which individuals learn to form and maintain relationships, skills that serve as a foundation for successful social interactions throughout adulthood. During this period, dynamic changes also occur in the brain, which could have life-long effects on social functioning. A longitudinal study of individuals early in their course of illness will provide a window into this critical phase of development, allowing us to examine potential mechanisms affecting social functioning in SZ. We recently proposed a theoretical model in which disrupted social preference and glutamate N-methyl-D-aspartate receptor (NMDAR) hypofunction are crucial to understanding social dysfunction in SZ. Social preference refers to the bias or tendency for individuals to prioritize processing of social over nonsocial stimuli. This model is based on convergent evidence from developmental science, clinical science, and behavioral neuroscience. This R01 aims to evaluate the above model using a longitudinal multimodal neuroimaging approach applied to seventy- two patients with first-episode SZ and seventy-two demographically matched controls. We will recruit patients immediately after their admission into the UCLA Aftercare Research Program, in which they will receive an intensive psychosocial intervention, including social cognitive training, for 6 months, as part of the Aftercare Program. Patients will be assessed at both baseline and 6 months; controls will be assessed only at baseline. Using functional magnetic resonance imaging (fMRI), we will measure neural activation by contrasting social versus nonsocial reward during a social preference task. Using proton magnetic resonance spectroscopy (1H MRS), we will obtain an index of glutamatergic activity (i.e., glutamate levels). The primary regions of interest for both fMRI and 1H MRS will be the ventral striatum and ventromedial prefrontal cortex. Social cognition and social functioning will also be assessed. With this design, we will determine whether 1) first-episode patients show aberrant neural activation and glutamate levels 2) longitudinal changes in neural activations and glutamate levels are associated with changes in social cognitive performance as patients receive integrated treatments after their first episode. As an exploratory aim, using a multimodal approach integrating fMRI, 1H MRS and behavioral assessment data, we will test associations among disrupted social preference, glutamate levels, and social functioning in patients early in their courses of illness. The findings of this project could provide a much-needed link between social dysfunction and the pathophysiological processes of schizophrenia as well as suggesting directions for potential therapeutic agents for social dysfunction that target the glutamatergic system.

NARRATIVE This project focuses on social preference, a key aspect of social processing that has been largely overlooked in schizophrenia research, and it evaluates a theoretical model, in which disrupted social preference and NMDAR hypofunction are crucial to our understanding of social cognitive impairment and social dysfunction in schizophrenia. The findings of this project could provide a much-needed link between social dysfunction and the pathophysiological processes of schizophrenia as well as suggesting directions for potential therapeutic agents for social dysfunction that target the glutamatergic system.