Abstract – Overall AIMINGS Center The vision of this proposed Artificial Intelligence, Modeling, and Informatics, for Nutrition Guidance and Systems (AIMINGS) Center is to implement computational and data science approaches and tools to advance nutrition for precision health in a way that accounts for the complex systems involved. Many existing data sets include extraneous data, making them difficult to analyze at best, and at worst, prone to generating misleading or biased insights. Thus, there is a need to for new approaches, methods, and tools to collapse and distill data to make them more Artificial Intelligence (AI)-ready and ready for a range of different analyses. This coincides with the goal of Project 1: to develop and utilize The Data Distiller for Precision Nutrition, a set of approached and tools that can collapse and distill nutrition-relevant data to create datasets that are AI- ready and ready for a range of other analyses. The first objective of the Nutrition for Precision Health (NPH) program is to “examine individual differences observed in response to different diets by studying the interactions between diet, genes, proteins, microbiome, metabolism and other individual contextual factors.” Given the type of missing data we face in nutrition, and the importance of establishing causal relationships rather than correlations, there is a need for new imputation methods. To address this, Project 2, the Causal Relationship Disentangler, will introduce new approaches for handling missing data while preserving causal structure. Learning how to transfer causal knowledge and doing so with missing data is critical for realizing the potential of nutrition for precision health. The NPH program’s other objectives are “to use AI to develop algorithms to predict individual responses to foods and dietary patterns,” and “to validate algorithms for clinical application.” This requires bringing different causal pathways together to understand how they interact. Agent-based models (ABMs) can help and serve as "virtual laboratories" to predict how different people may respond to a particular diet under different circumstances. Therefore, the goal of Project 3 (The Virtual Human for Precision Nutrition) is to develop an ABM tool that can help better understand and predict an individual's response to food and dietary patterns, while bringing together and accounting for the interactions between genetic, physiological, and behavioral factors. However, focusing on the individual alone will not be enough to address all aspects of NPH. Therefore, the Virtual Public Health Precision Nutrition Laboratory (Project 4) will develop ABMs that represent and account for the systems outside individuals such as their social, economic, and built environments. An Administrative and Coordination Core will oversee all operations and a pilot program. A Data Systems Core (DSC) will leverage the substantial computing resources of CUNY, West Point, and the Department of Defense to create a flexible cloud-based architecture for data flow and a collaborative workspace. A Computational Systems Core will provide resources and personnel to support the DSC and tool development/deployment.

Project Narrative-Overall AIMINGS Center The vision of this proposed Artificial Intelligence, Modeling, and Informatics, for Nutrition Guidance and Systems (AIMINGS) Center is to implement computational and data science approaches and tools to advance nutrition for precision health in a way that accounts for the complex systems involved. Such approaches and tools that help better understand and address the systems both within individuals and surrounding individuals could not only transform nutritional research and guidance, but also do so with other areas of health.