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Project Details

Functional analysis of SIRPG, a T cell-specific autoimmune gene

Project Number1R21AI169191-01

Contact PI/Project LeaderHO, I-CHENG

Awardee OrganizationBRIGHAM AND WOMEN'S HOSPITAL

Description

Abstract Text

Project Summary Recent genetic studies have identified numerous genetic variations that are associated with higher risk of autoimmune diseases. For example, several genetic variations at the SIRPG gene are associated with higher risk of type 1 diabetes. SIRPG is expressed almost exclusively in T lymphocytes. However, its physiological function is still unknown due to the lack of a mouse homologue. Nor do we understand how its genetic variations contribute to the pathogenesis of type 1 diabetes. These important questions will be addressed in this project with cutting edge genetic engineering technology to ablate SIRPG or reproduce its genetic variations in human T cells. Data generated from this project will advance our understanding of not only the function of SIRPG but also the pathogenesis of type 1 diabetes, and eventually lead to novel therapeutic approaches of autoimmune diseases.

Public Health Relevance Statement

Project Narrative Recent studies have identified many genetic variations that are associated with higher risk of autoimmune diseases; however, the impacts of the genetic variations on the function of immune cells are often unknown. Better understanding of how the variations influence the function of immune cells may lead to novel treatments of autoimmune disease and improve human health.

NIH Spending Category

Autoimmune DiseaseClinical ResearchGeneticsHuman Genome

Project Terms

AblationAddressAmino AcidsAntibodiesAutoimmuneAutoimmune DiseasesBiological AssayCD47 geneCell surfaceCellsClustered Regularly Interspaced Short Palindromic RepeatsCoculture TechniquesConflict (Psychology)ConsensusDataFamilyFlow CytometryGene Expression ProfileGenesGenetic EngineeringGenetic TranscriptionGenetic VariationGenetic studyGenomic DNAGenotypeGoalsHealthHomologous GeneHumanImmunoglobulinsIn VitroIndividualInsulin-Dependent Diabetes MellitusInterventionInvestigationLeadLupusMediatingMolecular ConformationMusNatural Killer CellsNucleotidesObservational StudyOutcomePathogenesisPathogenicityPhenotypePhysiologicalRoleSHPS-1 proteinSignal TransductionSingle Nucleotide PolymorphismSystemT-LymphocyteTechnologyUntranslated RNAVariantautoimmune pathogenesisbase editingcytokinegenome wide association studyhigh riskimmune functionimprovedmembermultiple omicsmultiple sclerosis patientnovelnovel therapeutic interventionreceptortranscriptome sequencing

Details

Contact PI/ Project Leader

Name

HO, I-CHENG

Title

ASSOCIATE RHEUMATOLOGIST

Contact

Other PIs

Not Applicable

Program Official

Name

MORRIS FEARS, MARGARET A

Contact

Organization

Name

BRIGHAM AND WOMEN'S HOSPITAL

City

BOSTON

Country

UNITED STATES (US)

Department Type

Unavailable

Organization Type

Independent Hospitals

State Code

Congressional District

Other Information

Opportunity Number

PA-20-195

Study Section

Cellular and Molecular Immunology - B Study Section[CMIB]

Fiscal Year

2022

Award Notice Date

28-January-2022

Administering Institutes or Centers

National Institute of Allergy and Infectious Diseases

CFDA Code

855

DUNS Number

030811269

UEI

QN6MS4VN7BD1

Project Start Date

01-February-2022

Project End Date

31-January-2024

Budget Start Date

01-February-2022

Budget End Date

31-January-2023

Project Funding Information for 2022

Total Funding

$268,500

Direct Costs

$150,000

Indirect Costs

$118,500

Year	Funding IC	FY Total Cost by IC
2022	National Institute of Allergy and Infectious Diseases	$268,500

NIH Categorical SpendingClick here for more information on NIH Categorical Spending

Funding IC	FY Total Cost by IC	NIH Spending Category
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES	$268,500	Autoimmune Disease; Clinical Research; Genetics; Human Genome

Sub Projects

No Sub Projects information available for 1R21AI169191-01

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for 1R21AI169191-01

Patents

No Patents information available for 1R21AI169191-01

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for 1R21AI169191-01

Clinical Studies

No Clinical Studies information available for 1R21AI169191-01

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