Summary/Abstract - P30GM133894 Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL), hereafter referred to as simply “Resource”, is to provide users access to integrated, mature SMB capabilities utilizing state-of-the-art synchrotron beam line facilities for macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small angle x-ray scattering/diffraction. These three areas comprise the Resource’s three Technical Operations Cores. Special emphasis is to create streamlined user access, provide dedicated user support and services, to train users, and to perform outreach on the scientific benefits of the capabilities of these specialized, yet mature facilities to the biomedical research community. Multiple innovative access mechanisms are being provided, that include both single- and multiple-technique approaches to access the Cores, based on a transparent and robust external peer-review process. A multifaceted training and outreach program includes individual training, workshops, summer schools, on-the-road, and support clinic segments by experienced scientific and technical staff. A Resource web portal provides streamlined scientific, technical, training, outreach and administrative material and other relevant information. A principal aim is to optimize and maintain, for reliable and forefront performance, experimental facilities and instrumentation, detectors, software and computing and network capabilities on the Resource’s 8+ beam lines at SSRL, capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3, and at the MFX station at LCLS. A multi-facility proposal mechanism facilitates access to complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user training, support and service, the Resource enables the scientific success for challenging and routine projects in the biomedical sciences.

Narrative Statement - P30GM133894 The purpose of the P30 Resource is to provide the biomedical community with access to state- of- the-art facilities for macromolecular crystallography, small-angle x-ray scattering, and x-ray spectroscopy/imaging, tools that are essential for the study of biological systems. They enable information that is prerequisite for understanding fundamentals of life, and provide methods that are central to the development of new therapeutics for human disease. The overarching goal is to provide an integrated Resource that makes mature technologies available to a broad research community, and provides researchers with expert support in their use.