Project Summary/Abstract Out-of-hospital cardiac arrest (OHCA) is a dynamic process that requires new interventions to improve outcomes. End-tidal carbon dioxide (ETCO2) measurement is a tool that is widely recognized, easy to use, and can potentially provide real-time insights into ongoing resuscitation efforts; however, it has yet to be applied to individualized medicine. Our overall hypothesis is that integrating ETCO2 capnography into OHCA resuscitation will improve outcomes. Using innovative signal processing and machine learning methods, we will identify a wide range of resuscitation quality characteristics over resuscitation, their relation to individual patient characteristics and predictability of OHCA outcomes. These goals will be accomplished via the following aims: Aim 1. Determine the influence of resuscitation interventions on real-time physiologic dynamics and outcomes in OHCA. Aim 2. Establish the influence of individual patient characteristics on the real-time physiologic dynamics and OHCA outcomes. Aim 3. Develop a novel cardiac arrest resuscitation strategy based upon real-time individualized physiologic dynamics. We will create a large repository of cardiopulmonary resuscitation process data encompassing data from over 5300 adult OHCA. This work will define intra-arrest ETCO2 dynamics over resuscitation to allow for the development of guided resuscitation efforts, and the resultant data will provide a solid foundation for future hypothesis-driven research. Dr. Nassal’s training plan encompasses both formal didactics and experiential training with experienced mentors and collaborators that will develop a skillset in both signal processing and equitable artificial intelligent driven algorithms. The team has extensive experience in using machine learning and multimodal signal processing for classification and predictions in resuscitation. This training program will develop a unique skillset in advanced cardiac signal processing; artificial intelligence, including equitable machine learning processing; and expertise in the application of these skills to develop dynamically guided resuscitation strategies that few other physician-scientist possess.

Project Narrative Out-of-hospital cardiac arrest (OHCA) is a major public health problem annually affecting close to half a million people in the US. As survival is only at 10%, new interventions that reflect the dynamic process during resuscitation are needed to improve outcomes. This proposal will define real-time physiologic dynamics in relation to patient specific characteristics and resuscitation interventions to develop new artificial intelligent driven resuscitation algorithms.