Project Abstract Alzheimer’s disease and related dementias (ADRD) are the most prevalent, debilitating neuro-degenerative diseases of aging, and current treatments for neuropsychiatric symptoms (NPS) (e.g., agitation, aggression, and depression) of ADRD are mixed. While non-pharmacological behavioral interventions are recommended as first-line treatments for these NPS of ADRD, they require substantial time and resources, and may be less effective for severely agitated, aggressive, or depressed older patients with ADRD. Electroconvulsive therapy (ECT) is an effective and safe treatment for a range of psychiatric disorders, including treatment-resistant depression, schizoaffective disorder, and bipolar disorder. Case series and uncontrolled naturalistic studies support preliminary evidence for the efficacy of ECT to treat severe agitation, depression, or other NPS in ADRD. Associations of ECT with long-term improvement in NPS and geriatric syndromes (e.g., functional disability and frailty), as well as with all-cause mortality rates among older adults with ADRD in nursing home settings are largely unexplored. The proposed nationwide cohort study explicitly addresses these knowledge gaps. Using the Centers for Medicare and Medicaid Services’ 2018-2020 Medicare claims data (Parts A, B, and D) linked to multiple data sources (e.g., Minimum Data Set [MDS] and National Death Index [NDI]), this proposed study features the following specific aims: 1) to examine incidence and prevalence rates of ECT use and socio-demographic and clinical factors associated with ECT use; 2) to investigate longitudinal associations of ECT with NPS and geriatric syndromes; and 3) to examine differential risks of all-cause mortality rates by ECT use among older adults with ADRD in nursing home settings. Longitudinal data analyses, such as generalized linear mixed modeling and competing-risk regression methods, will be used for Aims 2 and 3. In this nationwide cohort study, we will employ propensity-score matching and instrumental variable techniques to adjust for both observed and unobserved confounders. Intent-to-treat and as-treated analyses will also be conducted. Earlier studies support that ECT is associated with improvement in NPS of ADRD and our analyses show that ECT use with presence of both depression and ADRD was associated with a lower likelihood of all- cause mortality rates; we thus hypothesize that ECT may also be protective against geriatric syndromes. This is the first nationwide cohort study investigating the long-term effectiveness and safety of ECT among older adults with ADRD in nursing home settings. The proposed study is innovative since it will provide a better understanding of ECT use and its association with NPS, geriatric syndromes, and other related health outcomes. Findings from this study will inform clinical guidance on ECT use in older adults with ADRD in nursing home settings.

Project Narrative Electroconvulsive therapy (ECT) may be an effective treatment modality for severe neuropsychiatric symptoms (NPS) of Alzheimer’s disease and related dementias (ADRD). Using a nationwide, longitudinal cohort design, this study aims to examine associations of ECT with NPS and other key clinical outcomes among adults with ADRD in nursing homes. Findings will inform more effective clinical guidance on ECT use in nursing homes.