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Project Details

Defining epigenetic dysregulation in aged hematopoietic stem cells

Project Number1ZIAAG000987-06 NIDB ANNUAL REPORT

Contact PI/Project LeaderBEERMAN, ISABEL

Awardee OrganizationNATIONAL INSTITUTE ON AGING

Description

Abstract Text

We have generated transcriptional analysis (mRNA-seq) of HSCs isolated from replicates of young and old age populations. We have additionally evaluated 5 histone marks, ATAC-seq, and ChIP-seq from HSCs purified from both young and aged male C57Bl/6J mice. Age-related changes showed showed significant changes in bivalent domains, contact frequency and overall chromatin structure associated with to aberrant transcriptional profiles. We are currently working to publish these large dataset generated as a resource to the aging and stem cell community.

Public Health Relevance Statement

Data not available.

NIH Spending Category

AgingGeneticsHuman GenomeRegenerative MedicineStem Cell ResearchStem Cell Research - Nonembryonic - Non-Human

Project Terms

ATAC-seqAberrant DNA MethylationAddressAgeAgingAutomobile DrivingBiologyCaloric RestrictionCell CompartmentationCell physiologyCellsChIP-seqChromatin StructureCodeCollaborationsDNA MethylationEpigenetic ProcessFlow CytometryFrequenciesGene ExpressionGene Expression ProfileGenetic TranscriptionGenomicsHematopoietic stem cellsHistonesInterventionLaboratoriesLeadMalignant NeoplasmsMusPlayPublishingRNARNA analysisResourcesRoleTestingTranscriptional RegulationUntranslated RNAadult stem cellage relatedagedaging populationcell communitycircular RNAfunctional losshematopoietic stem cell aginghuman old age (65+)insightlarge datasetsmRNA sequencingmalepreventregeneration potentialsenescencestem cells

Details

Contact PI/ Project Leader

Name

BEERMAN, ISABEL

Title

Contact

Other PIs

Not Applicable

Program Official

Name

Contact

Email not available

Organization

Name

NATIONAL INSTITUTE ON AGING

City

Country

UNITED STATES

Department Type

Unavailable

Organization Type

Unavailable

State Code

Congressional District

Other Information

Opportunity Number

Study Section

Fiscal Year

2022

Award Notice Date

Administering Institutes or Centers

National Institute on Aging

CFDA Code

DUNS Number

UEI

Project Start Date

Project End Date

Budget Start Date

Budget End Date

Project Funding Information for 2022

Total Funding

$467,505

Direct Costs

Indirect Costs

Year	Funding IC	FY Total Cost by IC
2022	National Institute on Aging	$467,505

NIH Categorical SpendingClick here for more information on NIH Categorical Spending

Funding IC	FY Total Cost by IC	NIH Spending Category
NATIONAL INSTITUTE ON AGING	$467,505	Aging; Genetics; Human Genome; Regenerative Medicine; Stem Cell Research; Stem Cell Research - Nonembryonic - Non-Human

Sub Projects

No Sub Projects information available for 1ZIAAG000987-06

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for 1ZIAAG000987-06

Patents

No Patents information available for 1ZIAAG000987-06

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for 1ZIAAG000987-06

Clinical Studies

No Clinical Studies information available for 1ZIAAG000987-06

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