LEADERSHIP AND ADMINISTRATIVE CORE ABSTRACT The Native Elder Research Center (NERC) Resource Center for Minority Aging Research (RCMAR), located at University of Colorado-Denver and led by Drs. Spero Manson and Dedra Buchwald, has nurtured the next generation of faculty conducting health research with American Indian and Alaska Native (AI/AN) populations. Since 1998, 54 NERC Scientists (51 AI/AN) have accrued over $300 million in sponsored research and published 590 articles, and 26 are now tenured faculty. We propose to continue the mission of NERC, submitted by the Washington State University as a new application that reflects an institutional transition, and expand to include research with Native Hawaiians and Pacific Islanders. The Community Health and Aging in Native Groups of Elders (CHANGE) RCMAR will be led by 2 MPIs who each bring unique experiences and strengths to the program. Dr. Buchwald, MD, NERC Program Director since 1998, is a Professor in Washington State University’s College of Medicine and Director of the Institute for Research and Education to Advance Community Health. Julie Baldwin, PhD (Cherokee Nation of Oklahoma), is a Regents’ Professor of Health Sciences and Director of the Center for Health Equity Research at Northern Arizona University. A renowned Native scientist, she has 3 decades of experience leading health research with American Indian partners. Together, they will provide day-to-day and long-term leadership and oversight for all CHANGE components. The Specific Aims of this Core are to: 1) Support logistical operations, including but not limited to a) monitor adherence to required institutional, tribal, and federal policies and procedures; b) supervise fiscal activities and budget management; c) work with the REC to proactively recruit Native and other underrepresented minority early-stage investigators; and d) facilitate collaboration with the other RCMARs and the RCMAR Coordinating Center; 2) Implement and monitor activities, including to a) coordinate communication and effort within and between all CHANGE components; b) compile and disseminate program materials to CHANGE stakeholders; c) conduct program review and process evaluation to ensure appropriate and high-quality outcomes; and d) generate progress reports and respond to ad hoc requests from the RCMAR Coordinating Center and NIA; 3) Supervise interactions with regulatory bodies and sponsors, including to a) formalize agreements with community partners and Pilot Study participants; b) monitor Pilot Study administration, budgets, and compliance with Institutional Review Board and tribal review requirements; and c) promote collaboration with other NIH-funded programs and scientists engaged in aging research; and 4) Embed community outreach and engagement throughout the Center, including to a) engage with tribal providers and healthcare systems; b) ensure culturally desirable research topics, methods, and dissemination; and c) encourage CHANGE Scientists to grow relationships with community partners. NERC has made unparalleled contributions to increasing diversity among investigators conducting research with and for Native Elders. CHANGE will continue – and accelerate – these achievements.