Abstract We aim to develop tools for ground-truth phantoms for quantitative and structural MRI (qMRI). qMRI aims to acquire maps of physical or chemical variables that can be measured in physical units and compared between tissue regions and among subjects. In contrast, most clinical MRI acquisitions are only qualitative, i.e. “weighted images”, and not quantitative. While qMRI has the potential to improve precision diagnostics and medicine, it has been traditionally hampered by significant barriers such as imaging speed, computational practicalities, and reproducibility and repeatability of MR measurements. The variability between scanners and human subjects and the lack of ground truth in biological tissues fundamentally challenge the development, testing and standardization of qMRI techniques. The National Institute of Standards and Technology (NIST) hosted workshops working towards standardizing qMRI. The resulting recommendation paper highlighted a list of outstanding needs. The proposed project aims to address these unmet needs by developing materials, technology, tools and processes for manufacturing quantitative anthropomorphic MRI phantoms. Current state- of-the-art solutions for manufacturing MRI phantoms often use discrete compartments or geometrical shapes filled with chemical solutions representing a single physical parameter. In contrast, our proposed novel approach will enable fabrication of phantoms that truly mimic the contrast heterogeneity of tissue in 3D. These will include proton density, T1, T2, T2* relaxation times, magnetic susceptibility, diffusion, fat fraction, air-tissue field- inhomogeneity, relative conductivity, electric permittivity and magnetic permeability. If successful, this will be the first time that such a comprehensive set of MRI parameters is accomplished in a tissue-mimicking phantom. Based on our preliminary work on quantitative anatomy mimicking slice phantoms, we propose two approaches: (a) Quantitative 3D stack of thin slices. This approach is inexpensive, easy to reproduce by labs with moderate equipment and skills. (b) An advanced approach of boundaryless fully 3D phantoms that will be fabricated via inkjet 3D printing of hydrogels and plastics and would enable true high resolution 3D structures with heterogeneity that mimics human anatomy. In collaboration with leading industrial partners, we will validate and disseminate our technology. Our proposal is motivated by a rising need for quantitative measurements in MRI driven by precision medicine and the use of data science tools for biomarker discovery. With the rise of methods such as fingerprinting, and accelerated reconstruction, quantitative MRI (qMRI) is closer to the clinics than ever. The proposed quantitative MRI phantom will mimic the complexity of tissue structure and contrast mechanism that are necessary to ensure the accuracy of qMRI. If successful, the project will greatly facilitate the development and clinical translation of qMRI, making MRI accurate, precise, and quantitative – thus enabling precision diagnostic and discoveries that will directly improve healthcare.

Narrative The project aims to develop materials, technology, tools and processes for manufacturing quantitative anthropomorphic MRI phantoms that mimic multiple quantitative MRI parameters. This will be the first time that such a comprehensive set of MRI parameters is produced in a tissue-mimicking phantom. The project will greatly facilitate the development and clinical translation of quantitative MRI.