PROJECT SUMMARY The goal of this application is to further develop an integrated, multidisciplinary and translational Center for Childhood Obesity Prevention (CCOP) that will be sustained within the Arkansas Children’s Research Institute. Childhood obesity is a national public health threat that is disproportionately worse in Arkansas. In the United States, nearly 1 in 5 school age youth have obesity (1). Among school-age youth in Arkansas, 23% have obesity and 17% are classified as overweight (2). Further, the prevalence of hypertension (4-6), and other obesity-related co-morbidities, have increased dramatically over the last two decades. Additionally, obesity and obesity-promoting behaviors are also linked to a variety of cancers (16). To address this complex problem, a group of emerging scientists recruited in Phase 1 will continue to build their collaborative work in elucidating causes, and testing interventions, to stop the rise and ultimately reduce the prevalence of child overweight and obesity and corresponding comorbidities. In order to establish a broad-based, multi-disciplinary disease prevention center, rooted in a team science approach, projects span the full translational continuum, bringing together research in complex disease origins, epidemiology, and social systems. Ongoing recruitment of additional research project leaders and pilot study investigators will continue to build a critical mass of scientists focused on building the base of evidence for strategies to address the childhood obesity crisis and improve child health. Specific Aim 1: Further enhance the research infrastructure established in Phase 1 to support the Center. Critical institutional support and strong collaborations with multiple key institutional and community partners have been established, and will continue to be enhanced, to provide junior investigators’ access to state-of-the-art biomedical research facilities and resources to pursue inquiry focused on the theme of childhood obesity prevention. Specific Aim 2: Continue to build on the successful faculty development program implemented in Phase 1. The career development training program established in Phase 1 in partnership with the UAMS CTSA’s Research Fundamentals program will continue to be strengthened. A “best practices” senior mentoring program combines a Senior Mentor Rights and Responsibilities contract with guidance from a Senior Mentoring Leadership Team approach. Specific Aim 3: Ensure robust operations and pathway to sustainability for the Center for Childhood Obesity Prevention. Comprehensive operational procedures for managing the Center’s fiscal, regulatory, project development, and research core viability processes were established, and will continue to be strengthened. Significant institutional investment has been secured, and will be leveraged to ensure long term sustainability of the Center.

PROJECT NARRATIVE The goal of the Center for Childhood Obesity Prevention is to establish a broad-based, multi-disciplinary disease prevention center, rooted in a team science approach and spanning the full translational spectrum, to bring together research in complex disease origins, epidemiology, and social systems to address the childhood obesity crisis. Efforts will continue to build state-of-the-art institutional biomedical research infrastructure to support this goal, as well as continuing to build and train a critical mass of scientists focused on creating the base of evidence for strategies to improve child health.