Abstract Oklahoma faces a significant burden of cancer, with a high incidence and mortality rate. The impact of cancer is particularly profound among diverse communities, including Native American populations, making it a pressing concern for our state. Cancer poses a substantial challenge to the health and well-being of our residents, placing considerable social and economic strain on Oklahoma. The primary objective of this COBRE is to advance cancer research in Oklahoma. During Phase I and Phase II, our COBRE demonstrated remarkable progress. Supported Research Project Leaders secured competitive grants, including NIH R01 awards, Department of Defense grants, and esteemed foundation grants such as the American Cancer Society. Of the total of 375 papers that were published with acknowledgment to our COBRE, COBRE Research Project Leaders and Pilot Project Leaders authored 246 papers, all of them benefiting from COBRE and COBRE-funded Core support. The COBRE-supported Cores played a vital role in supporting multiple Investigators, facilitating publications, and aiding in acquiring federal grants, enriching cancer research in Oklahoma. Phase III seeks to build on this success, emphasizing sustainability and growth. For Phase III of the COBRE program, our vision is to build upon our prior achievements, fostering sustainability and growth. We remain dedicated to mentoring and supporting graduated Research Project Leaders. Our goal is to enhance Core facilities to accommodate evolving cancer research needs, transitioning them into institutional cancer research Cores. Committed to fostering cross- disciplinary collaboration and translational research, Phase III COBRE will innovate through the Pilot Grants Program. These concerted efforts are poised to further advance cancer research in our region, moving us closer to the coveted designation of a Comprehensive Cancer Center status for our NCI-designated cancer center. The establishment of such a center will revolutionize cancer prevention and treatment, benefiting our community and beyond. This Phase III COBRE marks a significant stride toward realizing our vision of a future free from the burden of cancer, where advanced research and improved clinical practices lead to better outcomes for all.

Project Narrative: Cancer research is a strategic area of research at the University of Oklahoma Health Sciences Center. The overarching objective of COBRE Phase III is to provide continued support for cancer researchers in Oklahoma by bolstering the research infrastructure dedicated to cancer research. We anticipate that the endeavors undertaken through COBRE Phase III will propel groundbreaking advancements in cancer prevention and treatment, offering hope and transformative treatments to cancer patients in Oklahoma. 1