OVERALL PROJECT SUMMARY The primary goal of this application is to continue to harness the capabilities of the Center for Pediatric Research to support basic and translational scientists studying mechanisms underlying children’s disease and associated treatment options. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These developmental processes are at the root of pediatric disease and are disrupted through genetic disorders, aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to characterize alterations during development as they pertain to pediatric diseases and disorders. For Phase III we will continue to build upon the success of Phase I and II efforts in creating a critical mass of independently funded investigators within the Center for Pediatric Research by refining our focus to support and mentor both new and established investigators. Center success will be achieved through the following Aims: 1) maintain a supportive environment for the training and mentorship of scientists studying pediatric disease to strengthen and grow the Center membership; 2) utilize and enhance existing Core resources that support pediatric research with a focus on long-term sustainability; 3) expand training and learning opportunities relevant to pediatric disease; and 4) evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research by fostering a collaborative environment for scientists and physicians. Strengthened by our institution’s strong commitment to children’s medicine, Phase III funding will be instrumental in enhancing pediatric research efforts in the Center, the region, and beyond.

OVERALL PROJECT NARRATIVE We will continue to develop a multidisciplinary research center focused on understanding and treating childhood diseases. The Center will sustain its supportive environment for scientists investigating the basis of and approaches to treat pediatric disease, specifically through high quality research Cores and sustained training and mentorship. Additionally, through careful and continual evaluation the Center will ensure its Cores and investigators are set up for success and self-sustainability post COBRE.