Abstract The All of Us Research Program (AoURP) awardee, the University of Arizona (UArizona)-Banner Health, has established a productive and beneficent consortium to generate well-engaged demographically and geographically diverse participation based on our Precision Engagement and Participant Journey models. Our successes include enrolling 68,500+ core participants across Arizona and Colorado of whom 84% represent at least one of the communities historically underrepresented in biomedical research (UBR). High UBR engagement and enrollment has set the cadence for continual forward momentum. Our team achieves innumerable wins via sustained, reliable participant outreach and protocol execution. As part of these diverse communities, the UArizona-Banner Health AoURP staff develop person-first, culturally and age-appropriate strategies to engage, enroll, and retain participants and partner with community-based organizations. Our improved retention rates are another success—currently at 38% active and an impressive 92% passive retention rates. The UArizona-Banner Health consortium has enrolled one of every four Hispanic, Latino, or Spanish participants in the national AoURP. From this foundation, we will evolve and innovate over the next five-year cycle and continue to reach UBR communities over a disparate geography. The UArizona-Banner Health consortium recognizes the importance of pivoting to reach UBR communities with distinct challenges, such as rural areas with low technology literacy and communities who experience generational mistrust in health research. Responding to these challenges and meeting such concerns is our ethos, which we call nuestro poder or our power. Accordingly, we propose to expand into Banner Health facilities and build effective partnerships for the UArizona-Banner Health Mountain Consortium in Arizona, Colorado, Wyoming, Nebraska, Nevada, Utah, and New Mexico. UArizona-Banner Health will function as a coordinating center in the Southwestern and Western U.S. to engage, enroll, and retain participants who reflect demographic vibrancy nationwide. By leveraging best practices and lessons learned in the initial five-year award, we will export our multipronged models to key partners in this wider region. In the new funding cycle, we will continue site activities, uphold AoU values, meet the regional expansion challenges, and sustain momentum. We will extend our reach by including new participants from pediatrics, 65+ communities, and rural areas, while we maintain the high quality of participant engagement, retention, and an overall UBR proportion >80%. Four specific aims will address Area of Interest 1, Tasks 1–5: 1. Implement a comprehensive engagement program that forms meaningful, lasting relationships with community-specific partners and individual participants, focusing on those from UBR backgrounds; 2. Contribute to the breadth and depth of the AoURP dataset by enrolling 11,300 participants in Year 1, and 60,000 diverse participants over five years, in new and existing geographies, eliminating technology access disparities to make AoURP accessible to anyone, anywhere; 3. Establish a relational and inclusive value-based approach to retention so that participants across UBR groups continue to provide high-quality data, increasing active retention to 40% and maintaining passive retention of 90%; and 4. Launch specialized engagement directed toward building awareness regarding AoURP pediatric enrollment, and following a successful 2023 micro-launch, include recruitment and retention to eligible prospective pediatric participants with their families as part of UArizona-Banner Health. The UArizona-Banner Health AoURP team will assess activity impacts, disseminate promising practices to the broader AoURP network, evaluate our initiatives against AoURP objectives and quality standards, and ensure our approach moves AoURP toward a more inclusive and equitable community, participant, and provider engagement, enrollment, and retention. We will continue to exceed these goals and maintain our excellence for the AoURP.