SysBio FAIRplex Abstract We propose building the SysBio FAIRplex, a FAIR PLatform for EXploration of Systems Biology, to accelerate the transformation of biomedical data from many sources into insights from many researchers into improved health for all. Our team includes leadership from the teams that built, harmonized, and manage platforms for many directly related projects, including AMP AD, AMP AIM, AMP CMD, AMP PD, AMP RA/SLE, AMP T2D, and the Global Parkinson’s Genetics Program (GP2). We have extensive governance, security, scientific, and technical experience with the realities and complexities of real-world execution, which we will use to mitigate legal, technical, contractual, and cross-organizational dependency risks. Our four Aims represent the four FAIR principles, which we will use to maximize the value of the AMP data ecosystem by (a) expanding the number and diversity of researchers who can find and access the data; (b) increasing the number and variety of tools that can be used to analyze the data; (c) enabling “big-N” science by combining silos into larger virtual cohorts; and (d) connecting the AMP ecosystem to the larger NIH and global data and research ecosystem. The SysBio FAIRplex system has three layers: ● Discovery via a single portal for researchers to find relevant data and tools ● Exploration and Analysis with a mix of graphical and computational tools, including the ability to transition from GUI to code ● Data, combining federated access to original data with Figure 1: The SysBio FAIRplex Portal provides a single point-of-entry for diverse centralized access to researchers, providing access to point-and-click exploration tools and to harmonized data. cloud-based analysis workspaces. We will take an iterative approach to implementation. ● We will start with early and broad activation of all workstreams in parallel, stakeholder engagement, and requirements clarification. ● We will then proceed with building initial prototypes of all systems on a subset of the data, including data harmonization, aggregate exploration, file search, and analysis workspaces. We will use those prototypes to get stakeholder feedback and to iterate on the requirements. ● Once the initial prototypes are up and running, we will iteratively add more data, add more tools, add more researchers, and gather more feedback. We are excited about the vision of the SysBio platform, and look forward to FAIRplex making it real.. SysBio ROA (OTA-24-008) 3