EXERCISE TRAINING IN FUNCTIONALLY IMPAIRED OLDER WOMEN
Project Number5R01AG011812-03
Former Number1P01AG010119-01A1
Contact PI/Project LeaderFIATARONE, MARIA A
Awardee OrganizationTUFTS UNIVERSITY BOSTON
Description
Abstract Text
Functional impairment becomes increasingly prevalent with age. Declines
in performance of the cardiovascular and musculoskeletal systems, whether
from specific diseases, undernutrition, or aging itself, may be
associated with impaired functional abilities. However, it is not known
if improvements in muscle function and endurance capacity achieved in
such a population would result in improved functional independence as
well. The proposed investigation would test the hypothesis that a year-
long exercise intervention in elderly women would result in clinically
important health benefits as defined by measures of functional status and
ambulatory abilities. In addition, the critical relationships
between nutritional status, energy expenditure, body
composition, physical functioning, and response to training in elderly
women will be explored.
One hundred community-dwelling women over the age of 70 with mild to
moderate functional impairment will be enrolled in a one year controlled
clinical trial. Subjects will be randomized to an experimental group
which will participate in three days per week of endurance and strength
training or a control group which will receive weekly mild stretching
exercises only. High intensity resistance training of the upper and
lower extremities will be achieved using dynamic weight machines and
static forearm exercise. Walking and stair climbing at moderate
intensity will comprise the endurance training intervention. At
baseline, 6 months, and post-training, subjects will be characterized
with respect to their body composition, nutritional status, endurance
capacity, muscle strength, gait and balance, functional status, and
physical and psychological health.
Public Health Relevance Statement
Data not available.
NIH Spending Category
No NIH Spending Category available.
Project Terms
balancebioenergeticsbody compositionclinical trialsexercisefemalefunctional abilitygaithuman old age (65+)human subjectimmunitylongitudinal human studymuscle strengthnutrient intake activitynutrition of agingnutrition related tagphysical fitnesstherapy compliancetraining
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