LEAD MOBILIZATION & BONE TURNOVER IN PREGNANCY/LACTATION
Project Number5R01ES007437-02
Former Number1R01HD032512-01
Contact PI/Project LeaderSCHOLL, THERESA O.
Awardee OrganizationUNIV OF MED/DENT NJ-SCH OSTEOPATHIC MED
Description
Abstract Text
Lead ingestion is considered a major public health problem for infants
and children with deleterious effects observed at lower blood lead
levels than previously believed. The investigators propose a
prospective study of 1000 pregnant women ages 11-30 years, in a
triracial community, to examine the role of maternal bone turnover
during pregnancy and lactation as a potential source of lead exposure
for the fetus and infant (during lactation). The lead sequestered in
maternal bone may be mobilized in the process of providing calcium for
the fetal and newborn skeleton. This prospective study will allow the
investigators to examine lead mobilization from bone turnover in still-
growing, adolescent and mature mothers. The specific aims are as
follow.
1: To measure maternal blood lead levels and bone (by ultrasound of the
os calcis and bone turnover markers) during pregnancy, to correlate
these measurements, and to describe them according to characteristics
of the mother.
2: To measure maternal blood lead levels and bone (by dual X-ray
densitometry, os calcis ultrasound and bone turnover markers) in
adolescent and adult women at parturition and at 3, 6, 12 months
postpartum to describe the association of these levels by breastfeeding
practice and/or maternal growth characteristics.
3: To measure the amount of lead in breast milk and to describe these
amount according to maternal bone turnover, growth, chronological and
gynecological age, and dietary practices.
4: To measure cord blood lead and whole blood lead in the infant at 6
months postpartum for correlation with maternal lead levels (both blood
and breast milk, if applicable), type of infant feeding (breast or
bottle feeding), and infant growth characteristics.
5: To relate maternal blood lead levels during pregnancy to maternal
blood pressure (during pregnancy), duration of gestation, and infant
birthweight. The investigators state that this study has important
public health ramifications for understanding if and how accelerated
bone turnover in reproduction can accelerate exposure to lead with
implications for maternal and infant morbidity.
Public Health Relevance Statement
Data not available.
NIH Spending Category
No NIH Spending Category available.
Project Terms
adolescence (12-20)blood chemistryblood pressurebone metabolismclinical researchdensitometrydevelopmental nutritiondietepidemiologyfemalegestational agehuman birth weighthuman milkhuman pregnant subjecthuman subjectinfant human (0-1 year)lactationleadlongitudinal human studymetal metabolismmother /infant health carenutrition related tagplacental transferpregnancy
National Institute of Environmental Health Sciences
CFDA Code
DUNS Number
140757589
UEI
Project Start Date
01-July-1996
Project End Date
30-June-2001
Budget Start Date
01-July-1997
Budget End Date
30-June-1998
Project Funding Information for 1997
Total Funding
$502,085
Direct Costs
$362,451
Indirect Costs
$139,634
Year
Funding IC
FY Total Cost by IC
1997
National Institute of Environmental Health Sciences
$502,085
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5R01ES007437-02
Publications
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