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Project Details

VIRAL NUCLEOTIDYLATION AND AUTOIMMUNITY

Project Number1R03AI042088-01

Contact PI/Project LeaderBLAHO, JOHN A.

Awardee OrganizationICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

Description

Abstract Text

IgM antibody specific for 2'-3' cyclic nucleotide phosphodiesterase I (CNPI), a protein enriched in oligodendrocytes and myelin membranes, is found in the cerebrospinal fluid and serum of 75 percent of patients with multiple sclerosis (MS). This project will explore the response to CNPI as a unique marker and specific probe for persistent viral infection in MS. The project will test the hypothesis that epitopes on CNP1 are structurally related to nucleotidyl moieties on herpes virus proteins. The specific aims of the project are to (1) isolate CNPI epitopes and confirm CNPI modification, (2) examine anti-CNPI IgM from MS sera for reactivity with known herpes virus proteins, and (3) use anti-CNPI IgM to isolate viral proteins from the brain of MS patients.

Public Health Relevance Statement

Data not available.

NIH Spending Category

No NIH Spending Category available.

Project Terms

2'3' cyclic nucleotide phosphodiesteraseantiviral antibodybiomarkergenetic mappingherpes simplex virus 1herpes simplex virus 2human tissueimmunoglobulin Mimmunoprecipitationmultiple sclerosisnervous system infectionprotein sequencevirus protein

Details

Contact PI/ Project Leader

Name

BLAHO, JOHN A.

Title

Contact

Other PIs

Not Applicable

Program Official

Name

Contact

Email not available

Organization

Name

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

City

NEW YORK

Country

UNITED STATES (US)

Department Type

NEUROLOGY

Organization Type

SCHOOLS OF MEDICINE

State Code

Congressional District

Other Information

Opportunity Number

PA-96-051

Study Section

Allergy, Immunology, and Transplantation Research Committee[AITC]

Fiscal Year

1997

Award Notice Date

21-September-1997

Administering Institutes or Centers

National Institute of Allergy and Infectious Diseases

CFDA Code

DUNS Number

078861598

UEI

C8H9CNG1VBD9

Project Start Date

30-September-1997

Project End Date

31-August-2000

Budget Start Date

30-September-1997

Budget End Date

31-August-1998

Project Funding Information for 1997

Total Funding

$84,750

Direct Costs

$50,000

Indirect Costs

$34,750

Year	Funding IC	FY Total Cost by IC
1997	National Institute of Allergy and Infectious Diseases	$84,750

Sub Projects

No Sub Projects information available for 1R03AI042088-01

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for 1R03AI042088-01

Patents

No Patents information available for 1R03AI042088-01

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for 1R03AI042088-01

Clinical Studies

No Clinical Studies information available for 1R03AI042088-01

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