MATHEMATICAL THEORY OF OSCILLATORY NEURAL NETWORKS
Project Number5R01MH047150-02
Contact PI/Project LeaderKOPELL, NANCY
Awardee OrganizationBOSTON UNIVERSITY MEDICAL CAMPUS
Description
Abstract Text
Oscillatory neural networks and oscillatory neurons are common in the
nervous system. Yet the function of neural networks that contain
OsCillatory elements is largely unexplored. The proposed work aims to
develop a body of technique relevant to addressing this relationship, and
to use this technique to further the understanding of some particular
neural networks. The work will focus on one vertebrate and one invertebrate
neural network, both central pattern generators (CPGS) engaged in producing
rhythmic motor output. In each case, the work will be collaborative with
neurophysiologists whose data will constrain the modelling activities.
The vertebrate CPG to be studied is that for undulatory locomotion; the
main experimental animal is the lamprey. This work continues a
collaborative effort to formulate and investigate a general and flexible
mathematical framework within which conclusions may be drawn from
experimental data on the lamprey about how the network functions. Work in
the immediate future will focus on the properties of long range coupling
among the ii local oscillatory elements, the implications of the design of
local networks for the global emergent behavior, and the interaction
between the neural behavior and the mechanical activity that it regulates.
Relevant experiments will be designed and carried out.
The invertebrate CPG is the crustacean stomatogastric ganglion (STG). This
work is part of a larger project involving modelling and experiments. Our
part of the project is to develop mathematics to help address such
questions as: (i) How can the behavior of the network be explained on the
basis of the properties of the component neurons? (ii) How do pacemaker and
emergent modes of oscillation, that are both known to exist in the STG,
interact and cooperate to produce stable and flexible system behavior?
Public Health Relevance Statement
Data not available.
NIH Spending Category
No NIH Spending Category available.
Project Terms
AgnathaCrustaceachordate locomotionganglionsmathematical modelneural information processingneuroanatomyneurobiologyneuromuscular systemneurophysiology
No Sub Projects information available for 5R01MH047150-02
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