A population-based case-control study is proposed to study the effect of
Chinese green tea on risk of stomach cancer. Based on findings from recent
experimental and epidemiologic studies it is hypothesized that the
consumption of green tea decreases the risk of stomach cancer and the
effect is stronger than that of the consumption of black tea. In light of
recent findings on the beneficial effect of garlic and allium vegetables on
stomach cancer risk, the study also proposes to examine whether these
vegetables consumed raw, semi-cooked, or fully-cooked form would confer the
same degree of protection. The study will be conducted at Hongko district
and Nanhui county, two areas of Shanghai, China. All the incidence cases
of primary stomach cancer occurring over a two-year period are eligible.
The community controls will be one-for-one matched to the cases on sex,
age, and area of residence. With the high incidence rate in this study
population, 800 cases and 800 controls are expected to be enrolled. Home
interview will be conducted to obtain information on type and frequency of
tea consumption, type and quantity of allium vegetables consumed separately
in raw, slightly cooked, or fully-cooked categories, dietary intake in four
different time periods corresponding to historical events in China,
education and occupation, tobacco and alcohol use, past medical history and
family medical history. Standard analytic methods for matched case-control
studies will be performed. Stomach cancer is prevalent in many parts of
the world. If green tea is found to protective, it would add to the
limited list of agents which have anticarcinogenic effect. Information on
the mode of allium vegetables intake and the stomach cancer risk will be
relevant for prevention application.
Public Health Relevance Statement
Data not available.
NIH Spending Category
No NIH Spending Category available.
Project Terms
Chinacancer riskcarcinogenesis inhibitorchemopreventionfood processing /preparationhuman subjectinterviewneoplasm /cancer epidemiologynutrition aspect of cancernutrition related tagquestionnairesstomach neoplasmsteavegetables
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