Methylphenidate, hydrochloride (CAS No. 298-59-9) will be administered in
feed to male and female F344/N rats and B6C3F1 mice for 104 weeks, in order
to determine the effects of chronic exposure. Interim tests (clinical
chemistry and hematology, clinical observations, and histopathology) will
be performed at 39 and 65 weeks of treatment. Clinical observations, body
weights, feed consumption, and histopathology on animals dying early, will
be performed routinely. This data will be used to determine: (1) target
organs related to treatment, (2) effects of treatment on central nervous
system, bone, weight gain, liver and kidney function, serum enzymes,
hematopoiesis, (3) difference in sensitivity between species and sexes, and
(4) carcinogenic potential.
National Institute of Environmental Health Sciences
CFDA Code
DUNS Number
UEI
Project Start Date
28-February-1986
Project End Date
30-December-1990
Budget Start Date
04-March-1991
Budget End Date
30-December-1990
Project Funding Information for 1991
Total Funding
$47,247
Direct Costs
Indirect Costs
Year
Funding IC
FY Total Cost by IC
1991
National Institute of Environmental Health Sciences
$47,247
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for N01ES065132-013
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for N01ES065132-013
Patents
No Patents information available for N01ES065132-013
Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for N01ES065132-013
Clinical Studies
No Clinical Studies information available for N01ES065132-013
News and More
Related News Releases
No news release information available for N01ES065132-013
History
No Historical information available for N01ES065132-013
Similar Projects
No Similar Projects information available for N01ES065132-013