Awardee OrganizationCINCINNATI CHILDRENS HOSP MED CTR
Description
Abstract Text
The assessment of disease outcome among patients with juvenile rheumatoid
arthritis (JRA) has been hampered by the lack of validated, sensitive
instruments for the measurement of functional ability. Existing studies
express outcome only in terms of process variables (number of joints with
swelling, etc.), broad functional status categories (Steinbrocker class),
or whether roentgenographic evidence of joint destruction has occurred.
The goals of the project are: (1) to describe disease outcome, expressed
as functional ability and chronicity, in a large cohort of patients who
have had JRA for a minimum of 5 years, and (2) to provide preliminary
data and feasibility information for a future project entitled,
"Predictors of Disease Outcome in JRA."
The specific aim is to generate a "status report" on the outcome of JRA,
expressed as functional ability and chronicity, based in the 1990's.
Patients who have had JRA 5 years or longer will be identified by
searching the computerized databank of the Special Treatment Center for
Juvenile Arthritis at Children's Hospital Medical Center, Cincinnati.
A standardized, well validated methodology for conducting disease outcome
studies developed at Stanford University will be used for contacting
potential subjects and obtaining the appropriate data. Patients or their
parents (estimated sample size is 400+) will be asked to complete either
the newly available Childhood Health Assessment Questionnaire or,
depending upon age, the Health Assessment Questionnaire. Information
obtained will be condensed into a "status report" on the outcome of JRA
based in the 1990's.
Long-term objectives and potential benefits include the following:
1. Future studies of disease outcome may use information from this
project as reference data to measure: (1) change in the long-term
outcome of JRA, and (2) the impact of new therapies now being developed.
2. The current project will provide preliminary data and feasibility
information for a future study, to be submitted as an R01 application
entitled, "Predictors of Disease Outcome in JRA."
National Institute of Arthritis and Musculoskeletal and Skin Diseases
CFDA Code
DUNS Number
071284913
UEI
JZD1HLM2ZU83
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Project Funding Information for 1994
Total Funding
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