RePORT ⟩ RePORTER

Project Details

APPLICATIONS OF NEW MASS SPECTRAL TECHNIQUES

Project Number1Z01CM006178-08

Contact PI/Project LeaderKELLEY, J A

Awardee OrganizationDIVISION OF CANCER TREATMENT

Description

Abstract Text

The objective of this project is research on and development of new mass spectral techniques in order to provide innovative and/or more rapid solutions to problems involving (1) chemical structure determination, (2) complex mixture analysis and (3) measurement of trace components in biological systems. Fast atom bombardment mass spectrometry and combined liquid chromatography-mass spectrometry remain the techniques of current interest. Reversed phase, paired-ion techniques are being developed for combining micro-column liquid chromatography with continuous-flow fast atom bombardment ionization for the on-line liquid chromatography-mass spectrometry analysis of nucleosides. Use of acidic, anionic surfactants during static fast atom bombardment greatly enhances sensitivity for analysis of cytosine nucleosides such as cyclopentenyl cytosine. The structure of an in vitro metabolite of benzene-3-carboxamide riboside, which is a potent inhibitor of inosine monophosphate dehydrogenase, has been confirmed as the adenine dinucleotide conjugate by negative ion fast atom bombardment mass spectrometry.

Public Health Relevance Statement

Data not available.

NIH Spending Category

No NIH Spending Category available.

Project Terms

analytical chemistrychemical structureenzyme inhibitorsion exchange chromatographyliquid chromatographymass spectrometrymethod developmentnucleic acid structurenucleosidesnucleotidessurfactanttrace elements

Details

Contact PI/ Project Leader

Name

KELLEY, J A

Title

Contact

Other PIs

Not Applicable

Program Official

Name

Contact

Email not available

Organization

Name

DIVISION OF CANCER TREATMENT

City

Country

UNITED STATES

Department Type

Unavailable

Organization Type

Unavailable

State Code

Congressional District

Other Information

Opportunity Number

Study Section

Fiscal Year

1993

Award Notice Date

Administering Institutes or Centers

National Cancer Institute

CFDA Code

DUNS Number

UEI

Project Start Date

Project End Date

Budget Start Date

Budget End Date

Project Funding Information for 1993

Total Funding

Direct Costs

Indirect Costs

Sub Projects

No Sub Projects information available for 1Z01CM006178-08

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for 1Z01CM006178-08

Patents

No Patents information available for 1Z01CM006178-08

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for 1Z01CM006178-08

Clinical Studies

No Clinical Studies information available for 1Z01CM006178-08

News and More

Section Menu