Cell signaling effected by tumor necrosis factor (TNF) is critical
for a number for immune processes. The signal is triggered by binding
of ligand to the TNF receptor at the cell surface and transmitted by
molecules that bind the cytoplasmic portion of the TNF receptors.
These binding proteins, called TRAFs, are novel proteins and their
function is still being characterized. We have produced crystals of a
TRAF molecule that diffract to high resolution and the crystals form
in space group R32 with a=b=85 E, c=320 E. We plan to use MAD phasing
to solve the structure.
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