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Project Details

ANTIBODY REPERTOIRE TO STREPTOCOCCAL PNEUMONIAE CAPSULAR POLYSACCHARIDES

Parent Project Number5M01RR001271-18

Sub-Project ID0255

Contact PI/Project LeaderLUCAS, ALEXANDER

Awardee OrganizationUNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Description

Abstract Text

Streptococcus pneumoniae is an encapsulated bacterial pathogen that causes serious invasive diseases. Considerable evidence indicates that antibodies directed against the capsular polysaccharides mediate protection against pneumococcal infection. However, little is actually known about the clonal and molecular diversity of these important antibody specificities. Our experimental aims are to evaluate the clonality, variable region usage and functional properties of adult antibodies specific for the pneumococcal polysaccharide serotypes 6B, 14 and 23F.

Public Health Relevance Statement

Data not available.

NIH Spending Category

No NIH Spending Category available.

Project Terms

Streptococcus pneumoniaeantibacterial antibodyantibody formationbacterial polysaccharidesclinical researchgene expressionhuman subjectimmunoglobulin genes

Details

Contact PI/ Project Leader

Name

LUCAS, ALEXANDER

Title

Contact

Other PIs

Not Applicable

Program Official

Name

Contact

Email not available

Organization

Name

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

City

SAN FRANCISCO

Country

UNITED STATES (US)

Department Type

Unavailable

Organization Type

Domestic Higher Education

State Code

Congressional District

Other Information

Opportunity Number

Study Section

Fiscal Year

1999

Award Notice Date

Administering Institutes or Centers

National Center for Research Resources

CFDA Code

DUNS Number

094878337

UEI

KMH5K9V7S518

Project Start Date

Project End Date

Budget Start Date

01-October-1998

Budget End Date

30-September-1999

Project Funding Information for 1999

Total Funding

$25,799

Direct Costs

Indirect Costs

Year	Funding IC	FY Total Cost by IC
1999	National Center for Research Resources	$25,799

Sub Projects

No Sub Projects information available for 5M01RR001271-18 0255

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for 5M01RR001271-18 0255

Patents

No Patents information available for 5M01RR001271-18 0255

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for 5M01RR001271-18 0255

Clinical Studies

No Clinical Studies information available for 5M01RR001271-18 0255

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