Awardee OrganizationUNIVERSITY OF PITTSBURGH AT PITTSBURGH
Description
Abstract Text
Subarachnoid hemorrhage (SAH) is a clinical emergency occurring to
healthy individuals that involves a sudden rupture of a cerebral
vessel and hemorrhage into the space between the brain arachnoidea.
If the person survives the initial SAH injury, 50 to 60% will develop
symptoms of impending delayed cerebral ischemia (DCI), 5-10 days
following the initial injury. There is evidence suggesting that
decreased cerebral oxygenation or brain activity from DCI may be
detected by multimodal neurophysiologic (NP) monitoring, however, no
systematic study has been undertaken to compare the sensitivity and
specificity of NP monitoring against the traditional standard of care
periodic clinical nursing neurologic assessment.
The purpose of this study is to examine the efficacy of bedside
multimodal NP monitoring compared to a routine neurologic examination
in the detection of the clinical emergency, DCI, in patients with
severe SAH. The specific aims of this project are to: 1) examine the
detection of DCI after SAH using either multimodal NP monitoring
(blood flow velocity, 2 indices of cerebral oxygenation and a single
index of brain electrical activity) in combination with the clinical
neurologic examination and 2) determine whether multimodal NP
monitoring detects DCI earlier when compared to the current standard
of care, the clinical neurologic examination. Using a within subject
repeated measure design, data will be collected on blood flow
velocity, two indices of cerebral oxygenation using near-infrared
technology and electroencephalography bispectral index as well as the
clinical neurologic examination from days 5 through 10 inclusive
following a severe SAH in 80 patients at risk for DCI.. Global
cerebral blood flow studies using 133 Xe at the bedside will be
conducted daily to examine trends in flow; the presence of DCI will
be verified by regional low flow as detected using xenon-enhanced
computed tomography CBF . Sensitivity and specificity will be
estimated and compared between the neurologic examination and the
individual methods of NP monitoring A one way within subjected
repeated measures analysis of variance will be used to compare the
time of detection by types of monitoring in patients with verified
DCI.
No Sub Projects information available for 5R01NR004339-02
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