LIFESTYLE, ADIPOSITY AND CARDIOVASCULAR HEALTH IN YOUTHS
Project Number1R01HL064157-01A1
Contact PI/Project LeaderGUTIN, BERNARD
Awardee OrganizationAUGUSTA UNIVERSITY
Description
Abstract Text
DESCRIPTION: (Adapted from the Investigator's Abstract) Rationale and long-term
objectives: Adult studies have shown that adiposity, especially visceral
adipose tissue (VAI), and cardiovascular (CV) fitness are key links between
lifestyle factors like diet and exercise on one hand, and CV disease on the
other. However, very little is known about these links during the juvenile
years, when the processes leading to CV disease are at an early stage of
development.
The specific aims are as follow: (1) to determine the relations of free-living
diet and exercise to total body percent fat ( percentBF), VAT and CV fitness in
black and white boys and girls of varying SES. (2) to determine the relations
of fatness and fitness to different CVD risk factors.
Design and methods: (1) Recruit 800 15 to 18 year olds, 200 in each ethnicity
and gender subgroup. (2) Assess diet with seven 24-hour recalls, and exercise
with two seven-day recalls and heart rate monitoring. (3) Measure percent body
fat with dual-energy x-ray absorptiometry, VAT with magnetic resonance imaging
and CV fitness with a multi-stage treadmill test. (4) Measure major fatness-
and fitness-related CV disease risk factors (e.g., total cholesterol:HDL
cholesterol ratio, insulin, systolic blood pressure, left ventricular mass
indexed to height, fibrinogen). (5) Conduct multivariate and univariate
analyses to determine relationships.
Health relatedness: The investigators state that the provided by this project
will assist in the formulation of effective lifestyle interventions targeted to
specific demographic groups for primary prevention of CVD, starting early in
life when the foundations for adult disease are being laid.
No Sub Projects information available for 1R01HL064157-01A1
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