The objectives of this contract are to determine the potential toxicity
and carcinogenicity of 6 chemicals via the oral route to F344 rats and
B6C3F1 mice. The project involves prechronic and/or chronic studies as
follows:
Sodium chlorate involves 21-day and 2-year studies via dosed water.
Special studies in the 21-day study include cell proliferation and
clinical laboratory studies.
Dibromoacetic acid involves 14-day, 90-day and 2-year studies via dosed
water. Special studies in the 90-day study include cell proliferation,
clinical laboratory studies, and SMVCE.
MX involves 14-day, 90-day and 2-year studies via dosed water. Special
studies in the 90-day study include clinical laboratory studies and
SMVCE.
Bromodichloromethane involves 21-day and 2-year studies via dosed water.
Special studies in the 21-day study include cell proliferation and
clinical laboratory studies.
2-Methylimidazole involves 2-year studies via dosed feed, with special
studies including thyroid hormones and UDP-GT.
4-Methylimidazole involves 2-year studies via dosed feed, with special
studies including thyroid hormones and UDP-GT.
National Institute of Environmental Health Sciences
CFDA Code
DUNS Number
006900526
UEI
CDZJAJJHJMH5
Project Start Date
30-January-1998
Project End Date
18-June-2001
Budget Start Date
18-November-1999
Budget End Date
05-November-2000
Project Funding Information for 2000
Total Funding
$725,000
Direct Costs
Indirect Costs
$395,549
Year
Funding IC
FY Total Cost by IC
2000
National Institute of Environmental Health Sciences
$725,000
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for N01ES085420-015
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for N01ES085420-015
Patents
No Patents information available for N01ES085420-015
Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for N01ES085420-015
Clinical Studies
No Clinical Studies information available for N01ES085420-015
News and More
Related News Releases
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History
No Historical information available for N01ES085420-015
Similar Projects
No Similar Projects information available for N01ES085420-015