Awardee OrganizationMASSACHUSETTS GENERAL HOSPITAL
Description
Abstract Text
This is a pilot study to determine the optimal length of dietary
intervention for subsequent studies. Normal women will be studied
during the early follicular phase of two consecutive menstrual cycles.
The women will be admitted to the GCRC for 3 days of a controlled diet,
which will consist of either 3 meals plus a snack daily, or the same
number of daily weight-maintenance calories given as a single evening
meal. On the third day of each diet, each subject will undergo 24 hours
of q15 minute frequent blood sampling for glucose and insulin. Each
women will undergo a 20 minute insulin tolerance test on the following
morning before discharge. The subjects will be readmitted in the
following early follicular phase for the same protocol on the oppsite
diet. Daily 24 hour urine collections will be made each day of each
admission to evaluate stress by urinary cortisol and catecholamine
levels. Six to eight normal women will be studied in this pilot to
determine if three days of a controlled diet are sufficient to induce
a change in insulin levels. Subsequently, the appropriate study length
will be utilized in future studies of hyperandrogenic and diabetic women
along with additional analyses.
No Sub Projects information available for 3M01RR001066-21 0231
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