Awardee OrganizationCHILDREN'S HOSP OF PHILADELPHIA
Description
Abstract Text
DESCRIPTION: (adapted from applicant's abstract) Previous studies have shown
that the GABA-A receptor subunit composition changes with development and with
certain seizure states such as status epilepticus (SE). The current proposal
tests the hypothesis that the slowly developing temporal lobe epilepsy (TLE)
often seen after SE is due to changes in the subunit composition. To test this
hypothesis, the PI uses the pilocarpine-induced SE model in developing rats.
Outcome measures of the GABA-A receptor are patch-clamping for conductance and
pharmacological response changes and single-cell RNA analysis of the recorded
cell. Similar studies will also be done in epileptic and non-epileptic
pediatric populations. Finally, the effect of GABA active drugs on GABA
receptor development will be examined.
National Institute of Neurological Disorders and Stroke
CFDA Code
853
DUNS Number
073757627
UEI
G7MQPLSUX1L4
Project Start Date
01-April-1999
Project End Date
31-March-2004
Budget Start Date
01-April-2001
Budget End Date
31-March-2002
Project Funding Information for 2001
Total Funding
$269,140
Direct Costs
$178,613
Indirect Costs
$90,527
Year
Funding IC
FY Total Cost by IC
2001
National Institute of Neurological Disorders and Stroke
$269,140
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5R01NS038595-03
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for 5R01NS038595-03
Patents
No Patents information available for 5R01NS038595-03
Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for 5R01NS038595-03
Clinical Studies
No Clinical Studies information available for 5R01NS038595-03
News and More
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History
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Similar Projects
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