Ribosomes are the complex assemblages of proteins and RNA chains
which are responsible for the synthesis of proteins. Low-resolution
structural maps, which have been generated by merging the data from
many separate structural studies, have not been sufficient to
elucidate many of the ribosome's most important structure/function
relations. Only atomic-resolution structure of the ribosome can
answer these questions. We plan to grow crystals of ribosomal
subunits from cultured human (HeLa) cells. Subunits have been
purified, and crystallization conditions will soon be tested.
No Sub Projects information available for 5P41RR001209-23 0198
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