Quantitation Of Biomarkers Of Oxidative Stress By Nici-m
Project Number1Z01ES050167-05
Contact PI/Project LeaderTOMER, KENNETH
Awardee OrganizationNATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Description
Abstract Text
In 1996 a workshop on Measurement of Oxidative Stress in Humans was held at NIEHS. There was a general consensus that it would be valuable to mount a study comparing various markers of oxidative stress measured from the same sample. One such marker is F2a-isoprostane which is quantitated by NICI-MS. Isoprostanes are prostaglandin-like compounds that are produced as a result of the chemical rather than enzymatic oxidation of arachidonic acid in membrane phospholipids. The isoprostanes have been shown to possess potent biological activity, and a number of studies have shown them to be accurate markers of lipid peroxidation in animal models of oxidative stress. The 8-iso-F2a-isoprostane has been the specific isomer quantified in most studies. The Mass Spectrometry Workgroup was asked to provide 8-iso-F2a-isoprostane analyses for NIEHS as part of the round-robin study of the various proposed biomarkers as well as to provide this capability to NIEHS scientists.
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Project Terms
alcoholic beverage consumptionantioxidantsbiomarkercarcinogenesiscarotenoidsclinical researcheicosanoidshuman datahuman tissuelipid peroxidesmass spectrometrynutrition aspect of cancernutrition related tagoxidative stressperoxidationprostaglandin analogstissue /cell culture
National Institute of Environmental Health Sciences
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