Novel CSF biomarker to predict impaired cognition in HIV
Project Number4R42NS046997-02
Contact PI/Project LeaderGIULIAN, DANA
Awardee OrganizationINFLAME THERAPEUTICS, INC.
Description
Abstract Text
DESCRIPTION (provided by applicant): The focus of this project is to explore the relationship between inflammatory cells and cognitive dysfunction in populations with HIV-1 infection. Extensive work has found that a biomarker is detected in lumbar cerebrospinal fluid of HIV(+) subjects with impaired cognition. Presently there are no suitable clinical tests to identify early neuro-inflammatory injury to neurons in such disorders as HIV-1 dementia. The ability to identify and treat HIV(+) populations before the onset of irreversible brain damage is highly desirable and forms the basis for this STTR proposal.
Public Health Relevance Statement
Data not available.
NIH Spending Category
No NIH Spending Category available.
Project Terms
AIDS /HIV neuropathyAIDS dementia complexbiomarkercerebrospinal fluidclinical researchcognitioncognition disordersdiagnosis design /evaluationdiagnostic testsearly diagnosishealth related legalhuman subjectlaboratory ratmental disorder diagnosisnervous system disorder diagnosisneural information processingneuropathologyneuropsychological testsneurotoxinspatient oriented researchsynapsestechnology /technique developmenttissue /cell culture
National Institute of Neurological Disorders and Stroke
CFDA Code
853
DUNS Number
170628619
UEI
Project Start Date
15-February-2004
Project End Date
31-July-2007
Budget Start Date
15-September-2004
Budget End Date
31-July-2005
Project Funding Information for 2004
Total Funding
$585,090
Direct Costs
$718,481
Indirect Costs
$163,832
Year
Funding IC
FY Total Cost by IC
2004
National Institute of Neurological Disorders and Stroke
$585,090
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 4R42NS046997-02
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for 4R42NS046997-02
Patents
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Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for 4R42NS046997-02
Clinical Studies
No Clinical Studies information available for 4R42NS046997-02
News and More
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History
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Similar Projects
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