This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) is among the most common endocrine disorders of premenopausal women, affecting 5-10% of this population. It has substantial reproductive and metabolic morbidities. This project supports Aims 1 and 2 of NIH P50 HD44405 and Aims 1 and 3 of "Genetic Mechanisms of Defects in Insulin Action in PCOS".