This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective is to investigate residual effect of heavy drinking, with or without hangover symptoms. The primary aim is to test several hypotheses about residual effect of heavy drinking. Hypotheses about how heavy drinking effect next- day performance include direct physiological effects of alcohol, alcohol withdrawal effects, and non-ethanol effects, such as congeners or family history of alcohol problems. We will test the following hypotheses: (1) relative to placebo, heavy drinking will degrade next-day performance, and this relationship will be mediated in full or in part by quality of sleep; (2) a high congener alcoholic beverage will affect performance to a greater degree than a low congener beverage and this relationship will be mediated by severity of hangover symptoms.