This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies have found that being overweight is a risk factor for recurrence and death from breast cancer. A study conducted at Wake Forest found that body size (weight or Body Mass Index) was found to be associated with all breast cancer recurrence and was found to be more pronounced for women with estrogen and progesterone receptor negative [ER/PR (-)] tumors. Treatment of obesity by weight loss through changes of diet and physical activity decreases blood markers connected to increased breast cancer risk. Meal replacement beverages have been found helpful for women who are unable to change their eating habits to begin losing weight. We will use a soy-based meal replacement beverage because studies have shown that soy protein has cholesterol and bone health benefits. Offering ER/PR negative breast cancer survivors an intervention that potentially reduces their risk of recurrence that also carries with it the added benefits of improving their general health, lipid profiles, and perhaps their quality of life seems highly desirable.