Core A: Human Tissue Acquisition and Cell Culture Laboratory INTRODUCTION. The availability of human tissues is a necessity for the conduct of experiments within each of the projects, and the investigators collectively have many years of experience with experimentation involving human tissue samples. The Program Project has for more than 20 years maintained an excellent working relationship with the Department of Pathology at our teaching hospital and with the staffs of the obstetric and gynecological services in the Department of Obstetrics and Gynecology. The current arrangement was built on that historical base and modified as needed to accommodate specific needs of the projects and to keep abreast of compliance issues related to use and procurement of human tissues. Working with components of the Administrative Core, this centralized process for collection, processing, and culturing of human tissues and cells has proven to be e'