This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The following summary is taken from the Keeney Lab we page:
"Meiotic recombination is initiated by DNA double-strand breaks (DSBs) generated by the topoisomerase-like Spo11 protein. We are studying the mechanism and regulation of Spo11-dependent DSB formation in the yeast S. cerevisiae, as well as examining the factors that dictate where Spo11 cleaves the DNA and that control the outcome of the recombination process."
Public Health Relevance Statement
Data not available.
NIH Spending Category
BiotechnologyGenetics
Project Terms
Cleaved cellComputer Retrieval of Information on Scientific Projects DatabaseDNADNA Double Strand BreakFundingGenetic RecombinationGrantInstitutionMeiotic RecombinationOutcomeProcessRegulationResearchResearch PersonnelResourcesSPO11 geneSaccharomyces cerevisiaeSourceSpo11 proteinTopoisomeraseUnited States National Institutes of HealthYeasts
No Sub Projects information available for 5P41RR000862-37 5125
Publications
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Clinical Studies
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