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Project Details

ARDS - EDEN OMEGA Protocol

Project NumberN01HR56173-10-0-3

Contact PI/Project LeaderHOUGH, TERRI

Awardee OrganizationUNIVERSITY OF WASHINGTON

Description

Abstract Text

¿ Objectives: 1. To assess the safety and efficacy of initial trophic enteral feeding followed by advancement to full-calorie enteral feeding vs. initial advancement to full-calorie enteral feeding management strategies in reducing mortality and morbidity in patients with ALI or ARDS 2. To assess the safety and efficacy of omega-3 fatty acid, gamma-linolenic acid, and anti-oxidant supplementation in reducing mortality and morbidity in patients with ALI or ARDS ¿ Hypotheses: 1. Initial trophic feeding followed by full-calorie enteral feeding will improve clinical outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by reducing systemic inflammation and the number of feeding complications as compared to early, full-calorie enteral feeding. 2. Omega-3 Fatty Acid, Gamma-linolenic acid (GLA), and anti-oxidant supplementation, as compared to placebo, will improve clinical outcomes (specifically increase the number of ventilator-free days to day 28 and decrease the 60-day, hospital mortality) in patients with ALI or ARDS by attenuating systemic inflammation.

Public Health Relevance Statement

Data not available.

NIH Spending Category

Acute Respiratory Distress SyndromeAssistive TechnologyBioengineeringClinical ResearchClinical TrialsComplementary and Alternative MedicineLungPatient SafetyRare Diseases

Project Terms

Adult Respiratory Distress SyndromeAlbuterolAntioxidantsAttenuatedBreathingCalendarClinicalClinical Trials Data Monitoring CommitteesDoseEnrollmentEnteral FeedingFeedsFutilityHospital MortalityHospitalsHourInflammationMechanical ventilationMonitorMorbidity - disease rateOmega-3 Fatty AcidsOutcomePatientsPhasePlacebosProtocols documentationRandomizedRandomized Controlled Clinical TrialsResearch DesignSafetySample SizeSupplementationVentilatorVital Statusbasedesignfeedinggamma-Linolenic Acidimprovedmortalitypatient safetyprospectivesafety study

Details

Contact PI/ Project Leader

Name

HOUGH, TERRI

Title

Contact

Other PIs

Not Applicable

Program Official

Name

Contact

Email not available

Organization

Name

UNIVERSITY OF WASHINGTON

City

SEATTLE

Country

UNITED STATES (US)

Department Type

Unavailable

Organization Type

Domestic Higher Education

State Code

Congressional District

Other Information

Opportunity Number

Study Section

Fiscal Year

2011

Award Notice Date

Administering Institutes or Centers

National Heart Lung and Blood Institute

CFDA Code

DUNS Number

605799469

UEI

HD1WMN6945W6

Project Start Date

30-September-2005

Project End Date

30-November-2011

Budget Start Date

Budget End Date

Project Funding Information for 2011

Total Funding

$270,496

Direct Costs

Indirect Costs

Year	Funding IC	FY Total Cost by IC
2011	National Heart Lung and Blood Institute	$270,496

NIH Categorical SpendingClick here for more information on NIH Categorical Spending

Funding IC	FY Total Cost by IC	NIH Spending Category
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE	$270,496	Acute Respiratory Distress Syndrome; Assistive Technology; Bioengineering; Clinical Research; Clinical Trials and Supportive Activities; Complementary and Integrative Health; Lung; Patient Safety; Rare Diseases

Sub Projects

No Sub Projects information available for N01HR56173-10-0-3

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for N01HR56173-10-0-3

Patents

No Patents information available for N01HR56173-10-0-3

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for N01HR56173-10-0-3

Clinical Studies

No Clinical Studies information available for N01HR56173-10-0-3

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