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Project Details

Efficacy of Eldecalcitol (ED-71) in Colorectal Cancer

Project Number261201200015I-0-26100005-1

Contact PI/Project LeaderPAWLITA, MICHAEL

Awardee OrganizationRESEARCH INST OF FOX CHASE CAN CTR

Description

Abstract Text

The overall objective is to develop Eldecalcitol (ED-71) for colorectal cancer prevention in a preclinical model. Specifically, the Contractor shall obtain required quantities of ED-71, establish the optimal dose and/or non-calcemic dose, perform in depth assessment of ED-7-mediated colon cancer prevention in APC-min mice, in addition to, identifying ED-71 specific molecular target(s) in preventing tumor frequency, incidence, multiplicity, etc. in APC-min mice.

Public Health Relevance Statement

Data not available.

NIH Spending Category

CancerColo-Rectal CancerDigestive DiseasesNutritionPrevention

Project Terms

AgeAnimalsApoptosisBiological MarkersBlood Chemical AnalysisBlood specimenBody WeightBreedingCarbon DioxideCell ProliferationChemopreventive AgentCholecalciferolColon CarcinomaColonic NeoplasmsColonic PolypsColorectal CancerContractorContractsControl GroupsDietDoseEffectivenessEuthanasiaFemaleFrequenciesGene Expression ProfileGeneticImmunohistochemistryIncidenceIntestinal NeoplasmsIntestinesLiverMediatingMessenger RNAMethodsMicroRNAsMolecular TargetMusOrganPre-Clinical ModelReverse Transcriptase Polymerase Chain ReactionSerumSerum Calcium LevelSignal TransductionSignaling MoleculeSmall Intestinal NeoplasmSmall Intestinal PolypStagingSymptomsTestingTissuesToxic effectTumor SuppressionTumor TissueWestern Blottingbasecancer preventioncolorectal cancer preventionfeedingin vivomalemouse modelpreventresearch studyresponsetumor

Details

Contact PI/ Project Leader

Name

PAWLITA, MICHAEL

Title

Contact

Other PIs

Not Applicable

Program Official

Name

Contact

Email not available

Organization

Name

RESEARCH INST OF FOX CHASE CAN CTR

City

PHILADELPHIA

Country

UNITED STATES (US)

Department Type

Unavailable

Organization Type

Research Institutes

State Code

Congressional District

Other Information

Opportunity Number

Study Section

Fiscal Year

2013

Award Notice Date

Administering Institutes or Centers

National Cancer Institute

CFDA Code

DUNS Number

064367329

UEI

FF1XVJMDYVR1

Project Start Date

18-September-2013

Project End Date

17-September-2014

Budget Start Date

Budget End Date

Project Funding Information for 2013

Total Funding

$303,650

Direct Costs

Indirect Costs

Year	Funding IC	FY Total Cost by IC
2013	National Cancer Institute	$303,650

NIH Categorical SpendingClick here for more information on NIH Categorical Spending

Funding IC	FY Total Cost by IC	NIH Spending Category
NATIONAL CANCER INSTITUTE	$303,650	Cancer; Colo-Rectal Cancer; Digestive Diseases; Nutrition; Prevention

Sub Projects

No Sub Projects information available for 261201200015I-0-26100005-1

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for 261201200015I-0-26100005-1

Patents

No Patents information available for 261201200015I-0-26100005-1

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for 261201200015I-0-26100005-1

Clinical Studies

No Clinical Studies information available for 261201200015I-0-26100005-1

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