Receptor-based developmental and reproductive toxicity of Superfund chemicals
Project Number5P42ES007381-19
Contact PI/Project LeaderSHERR, DAVID H
Awardee OrganizationBOSTON UNIVERSITY MEDICAL CAMPUS
Description
Abstract Text
The scientific theme for the Superfund Research Center at Boston University is receptor-based toxic effects of Superfund chemicals on development and reproduction in humans and wildlife. The chemicals under study are organic compounds of special interest to the SRP Center mandate that initiate their toxic actions by interacting with specific molecules inside cells called receptors. This interaction sets in motion chain of events that often leads to production of new proteins that alter the development of the cells. The research ranges from basic laboratory investigations to large scale epidemiologic studies of populations exposed through drinking water or around a Superfund site or molecular studies of fish ecology in a contaminated harbor. The object is to gain a better understanding of the implications of disturbances of reproductive and developmental processes, including aging, from exposures to hazardous substances in the environment.
A special feature is a coordinated set of parallel projects examining molecular and population effects of developmental toxins in the standard laboratory zebra fish model and a widespread environmental sentinel, the killifish. Epidemiological studies of developmental outcomes from exposure to the high-prevalence Superfund chemicals perchloroethylene (PCE, tetrachloroethene), PCBs, the pesticide methoxychlor, phthalate, organotins and metals target knowledge gaps identified as special research needs by EPA/Agency for Toxic Substances and Disease Registry (ATSDR). A major feature is development of novel methods to address some of the most difficult problems associated with the typical hazardous waste epidemiological and toxicological datasets, temporal spatial distribution and interaction in mixtures. A Research Support Core provides expertise for highly sophisticated data analysis of Next Generation Sequencing and computer modeling of molecular structures, techniques used by five of the seven research projects. The Center includes two Core facilities dedicated to translating research for use in risk assessment by state and federal agencies and engaging the public and local health authorities in framing and shaping the scientific research agenda.
Public Health Relevance Statement
US EPA and other regulatory agencies within the Federal system have a special interest in the possible reproductive and developmental effects of hazardous substances, including, but not limited to, those caused by endocrine disrupting agents. Despite increasingly sophisticated research, there is still much to learn about the seriousness of the problem.
National Institute of Environmental Health Sciences
CFDA Code
143
DUNS Number
604483045
UEI
FBYMGMHW4X95
Project Start Date
01-April-1997
Project End Date
31-March-2016
Budget Start Date
01-April-2015
Budget End Date
31-March-2016
Project Funding Information for 2015
Total Funding
$2,312,792
Direct Costs
$1,900,909
Indirect Costs
$778,281
Year
Funding IC
FY Total Cost by IC
2015
National Institute of Environmental Health Sciences
$2,312,792
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5P42ES007381-19
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for 5P42ES007381-19
Patents
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Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for 5P42ES007381-19
Clinical Studies
No Clinical Studies information available for 5P42ES007381-19
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History
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Similar Projects
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