ABSTRACT Consistent with the Center’s theme, the mission of Core E is to facilitate a broad range of biological and behavioral intervention studies that are designed to optimize psychiatric, behavioral, and medical outcomes among persons with HIV (PWH). During next funding cycle the Core E will continue to offer basic panel assays (Aim 1) and sample repository (Aim 4) for all Pilot Projects, as well as design and implement novel assays and encourage utilization of omics (Aim 2) and MRI technology (Aim 3) where appropriate. This Core will perform laboratory and imaging assessments that define the mental illnesses and comorbidities related to HIV/AIDS and unique modeling and measurements related to various behavioral and pharmacologic interventions. The Core will benefit from the major strengths of the Perelman School of Medicine (PSOM), Children's Hospital of Philadelphia (CHOP), Centers, Departments, and Schools at the University of Pennsylvania (Penn) and Wistar Institute. We will identify specific and potentially unique biomarkers which are related to mental illness and to comorbidities of HIV/AIDS. These data will be collected for all subjects to be studied in pilots and other Cores. The Core will perform assays of body fluids and cells including markers of immunity, inflammation, stress, and health. The Core will also carry out neuroimaging and provide guidance on neurocognitive measures. The Core will perform assessments related to therapeutics for HIV, mental health, and comorbidities. The Core is directed by two senior investigators, Drs. Jordan-Sciutto, and Gur. Dr. Douglas will retain a consulting role with the Core and will continue to advise Drs. Jordan-Sciutto, and Gur in all aspects of the Core. The Core will support the Center’s scientific agenda and developmental program. This Core resource will closely interact with existing resources at Penn, which are central to the mission of the PMHARC. The Core PIs, Drs. Jordan- Sciutto, and Gur, are in leadership roles at Penn. The Core will be uniquely positioned to carry out and monitor the quality control and quality assurance of standardized selected imaging, biochemical markers, neuropsychological behavioral testing, and laboratory testing. The Core will work closely with all the other PMHARC Cores, and most closely with the Clinical Assessment Core, in an effort to gather integrated 'state-of- the-art' biomedical and behavioral data on a cohort of PWH with a variety of mental illnesses in an effort to better understand disease trajectories, morbidities and clinical outcomes.

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