ADMINISTRATIVE CORE ABSTRACT The Administrative Core is the central hub for all activities of the proposed Translational Center for Microphysiological Systems-Based Drug Development Tools for Pregnancy and Women's Health. The Core will be coordinating activities across three laboratories at two institutions (University of Texas Medical Branch at Galveston and Texas A&M University in College Station) and ensuring that the overall goal of the Center, which is “to translate a comprehensive set of MPS aimed at replicating all aspects of human female reproductive organs involved in pregnancy into drug development tools that are qualified for regulatory decision-making,” is met. The Core is organized around four key functions that will enable it to be an effective and nimble coordinator of the proposed research, outreach, training, and translation activities: (1) administration and fiscal management, (2) research integration, (3) quality control and quality assurance, and (4) research translation and commercialization. The Core will be physically located within the Division of Basic Science and Translational Research in the Department of Obstetrics & Gynecology at UTMB. The overall PI, Dr. Menon is director of the Division, and he will be assisted in the Core by TAMU MPIs, Drs. Rusyn and Han; together, three MPIs will form a Steering Committee that will oversee all functions of the Core and the Center. The MPIs have extensive experience working together through joint funding, publications, and co-mentoring of trainees. Other personnel in the Core include Center Manager and Quality Assurance/Quality Control Manager. The overall strategy used by the Administrative Core for achieving success will consist of: (i) regular Center-wide and inter-core interactions; (ii) monthly tracking of the products of the Center’s work (preparation of the resources, delivery of the resources to the QC, completed qualification experiments, qualification package submissions to the FDA, and interactions with stakeholders); and (iii) coordinating research translation. The Core’s work is organized around five Specific Aims. First, the Core will provide effective administrative and fiscal management. The Core will conduct program planning and evaluation and assessment of Center performance. Second, the Core will facilitate integration of cutting-edge research, qualification, and regulatory science activities. Third, the Core will establish and maintain quality assurance and control protocols for both resources, experiments, and data to ensure rigor and reproducibility in research and to maintain FAIR data management system through integration with the MPS Database. Fourth, the Core will promote dissemination of the Center’s knowledge to other academic researchers, government agencies, and the industry end-users. Finally, the Core will advance the practical application of the Center-qualified MPS as drug development tools through technology transfer and commercialization. All Center faculty and staff will interact with the Core as it executes its Administration, Integration, Quality Assurance/Quality Control, and Technology Transfer & Commercialization functions.