TIME-RESTRICTED FEEDING FOR PANCREATIC CANCER PREVENTION
Project Number75N91024D00004-0-759102400002-1
Contact PI/Project LeaderVILAR SANCHEZ, EDUARDO
Awardee OrganizationUNIVERSITY OF TX MD ANDERSON CAN CTR
Description
Abstract Text
The overarching goal of this Task Order is to determine the efficacy of time-restricted feeding (TRF) on PanIN prevention in a mouse model of pancreatic cancer and identify efficacy
biomarkers. The preliminary results suggest fasting regimens are feasible and safe interventions which can
modulate PDAC tumor growth, immune infiltration and microbiome composition. Short-term and long-term TRF
interventions will be conducted to study PanIN progression and PDAC development in KC mice in order to
identify and validate non-invasive biomarkers of treatment efficacy.
Public Health Relevance Statement
Data not available.
NIH Spending Category
No NIH Spending Category available.
Project Terms
Biological MarkersDevelopmentDietFastingGoalsInterventionMalignant neoplasm of pancreasMusPancreatic Intraepithelial NeoplasiaPreventionRegimenTime-restricted feedingTreatment Efficacybiomarker identificationcancer preventionefficacy evaluationimmune cell infiltratemicrobiome compositionmouse modelpancreatic cancer modeltumor growth
No Sub Projects information available for 75N91024D00004-0-759102400002-1
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