Advancing and applying peripheral and central auditory findings in HIV/AIDS.
Project Number5R01DC020135-03
Former Number1R01DC020135-01
Contact PI/Project LeaderBUCKEY, JAY C
Awardee OrganizationDARTMOUTH COLLEGE
Description
Abstract Text
With NIH support, the Ubongo Sikivu cohort of both people living with HIV (PLWH) and uninfected controls
was established in Tanzania and has had regular assessments of their peripheral hearing ability over 10+
years with detailed central auditory and neurocognitive assessments added over the last 5 years. This cohort is
uniquely positioned to address the issues posed by PAR-20-127 “Advancing HIV/AIDS Research within the
Mission of the NIDCD.” Data from the cohort has already answered important questions about the ototoxicity of
anti-retrovirals, the effects of HIV infection and treatment on both peripheral and central hearing parameters,
and the relationship of central auditory test (CAT) results to neurocognitive performance. By following this
cohort longitudinally questions about how CATs could be used to predict or track neurocognitive performance
and how age and long-term anti-retroviral treatment affect the auditory system can be answered. To date, the
most significant result has been demonstrating that CAT results correlate with cognitive performance. This
suggests CAT results might be useful for forecasting or tracking cognitive decline over time. The next important
steps are determining whether worsening CAT performance precedes the later development of cognitive
deficits in PLWH and which central auditory tests and other variables can predict neurocognitive deficits
accurately. Neurocognitive screening tests are often sensitive to education, literacy, and culture. Full
neurocognitive test batteries can be difficult to employ, particularly in the developing world where clinician time
is limited, few trained personnel are available, and normative data often do not exist. Using CATs would be a
major advance for following HIV+ patients because the CATs can be short (a gap detection test takes 5
minutes), easy to explain (the hearing-in-noise test and triple digit task involve identifying words or numbers in
background noise), or effortless for the subject (the FFR test requires no subject input at all). This project’s
goal is tracking the trajectory of peripheral auditory, central auditory, and neurocognitive performance over time
by continuing to follow this cohort. With these longitudinal data machine learning and other statistical
techniques will be applied to assess which factors forecast the subsequent development of cognitive deficits
and which factors or combination of factors identify those with existing neurocognitive deficits. An international
team with experience in central auditory testing and neurocognitive testing in PLWH has been assembled. Dr.
Nina Kraus and her Northwestern team are internationally recognized experts in the auditory FFR. The Dar es
Salaam team has extensive experience in otolaryngology and performing peripheral auditory, central auditory,
and neurocognitive tests. Drs. Roth and Boivin are experts in assessing neurocognitive function. Dr. Gui has
diverse biostatistical experience. Dr. Niemczak is an expert in peripheral and central auditory processing. This
team and longitudinal cohort offer the unique ability to assess the use of CATs in evaluating cognition as well
as the effects of aging and medications on both central and peripheral auditory function in PLWH.
Public Health Relevance Statement
Project Narrative
This study will study a unique cohort including both people living with HIV and uninfected controls in Tanzania
to determine whether central auditory tests could predict the subsequent development of cognitive programs or
screen for cognitive problems in those with HIV. This could alter clinical practice if these easy-to-perform
central auditory tests could be used clinically to screen for or track central nervous system effects in people
living with HIV This study will also evaluate the long-term auditory effects of HIV infection and treatment.
NIH Spending Category
No NIH Spending Category available.
Project Terms
AddressAffectAgeAgingAnti-Retroviral AgentsAudiologyAuditoryAuditory systemBiometryBrainCentral Nervous SystemClinicalCognitionCognitiveCognitive deficitsCollaborationsComplexDataDevelopmentDigit structureEducationEvaluationFutureGoalsHIVHIV InfectionsHIV/AIDSHearingHearing TestsHuman ResourcesImpaired cognitionIndividualInternationalLongitudinal StudiesLongitudinal cohortLongitudinal cohort studyMachine LearningMeasuresMissionNational Institute on Deafness and Other Communication DisordersNeurocognitiveNeurocognitive DeficitNoiseOtolaryngologyParticipantPatientsPerformancePeripheralPersonsPharmaceutical PreparationsPositioning AttributeResearchSensitivity and SpecificityTanzaniaTechniquesTest ResultTestingTimeTrainingUnited States National Institutes of HealthWorkage accelerationage effectantiretroviral therapyauditory processingclinical practicecognitive performancecognitive processcognitive testingcohortcomorbiditycomparison controldetection testexperiencefollow-upinnovationinterestliteracylongitudinal datasetneurocognitive testototoxicityperformance testsprogramsresponsescreeningsoundspeech in noisetreatment response
National Institute on Deafness and Other Communication Disorders
CFDA Code
173
DUNS Number
041027822
UEI
EB8ASJBCFER9
Project Start Date
01-July-2022
Project End Date
30-June-2027
Budget Start Date
01-July-2024
Budget End Date
30-June-2025
Project Funding Information for 2024
Total Funding
$688,741
Direct Costs
$550,399
Indirect Costs
$138,342
Year
Funding IC
FY Total Cost by IC
2024
National Institute on Deafness and Other Communication Disorders
$688,741
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5R01DC020135-03
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for 5R01DC020135-03
Patents
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Outcomes
The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.
No Outcomes available for 5R01DC020135-03
Clinical Studies
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History
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