PROJECT SUMMARY/ABSTRACT
This proposal is the third renewal application for support of the Pediatric Physician-Scientist T32
training program in the Department of Pediatrics (DOP) at Washington University School of Medicine (WUSM).
Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet
the ongoing national need to replenish the pediatric physician-scientist pipeline at the clinical post-postdoctoral
fellowship level, our program supports a mentored career development pathway for 4 Trainees per year
(typically for 2 years each) by leveraging a wealth of biomedical research resources across the WUSM
campus, the DOP and our Child Health Research Center (NICHD CHRCDA K12). For the past 20 years and
going forward, the long-term objective of this program is to develop Trainees who focus their research efforts
on pediatric disease-oriented biology by applying recent advances in the basic and translational sciences, such
as developmental biology, cell biology, immunology, genetics, multi-omics systems biology, and bioinformatics.
The specific aims of this proposal include: 1) a protected mentored research experience with a well-established
investigator across a wide range of disciplines related to child health within WUSM and the DOP, 2) obligatory
educational programs in laboratory management, scientific rigor, statistics, grantsmanship, responsible
conduct of research, and biomedical informatics, 3) individualized coursework based on the Trainees area of
investigation (e.g., genetics, cell biology, computational biology), 4) continuous feedback to the Trainee,
mentor and program leadership, and 5) a flexible environment that facilitates the development of Trainees who
are women and are under-represented minorities. The program, now 20 years old, has an excellent track
record by exceeding national benchmarks (15-year T to K conversion rate = 52%; this cycle = 57%), and will
ultimately close the knowledge gap between basic/translational scientists and pediatric clinicians. Gary A.
Silverman, M.D., Ph.D., and David Hunstad, M.D. again serve as the Program Director, and the Training
Director, respectively. Our Trainees will continue to utilize a vast array of institutionally funded, state-of-the-art
research core facilities that provide, for example, whole-genome/exome DNA sequencing, single-cell RNA
sequencing, induced pluripotent stem cells and organoids, bioinformatics, cryo-EM and other advanced
imaging, CRISPR-CAS9 genome editing and model animal development, to facilitate the study of pediatric
disease states. The long-term goals of this program are being realized as its Trainees contribute to our
understanding of development and childhood diseases for decades to come, while evolving into the next
generation of scientific leaders, role models, and mentors for subsequent generations of pediatric physician-
scientists.
Public Health Relevance Statement
PROJECT NARRATIVE
Pediatric physician-scientists play a vital role in advancing knowledge related to child health. There
remains a national need to stimulate child health research by enhancing the training of early-stage pediatric
physician-scientists. This program supports the mentored career development of pediatric physician-scientists
by optimally leveraging the resources of the Washington University School of Medicine as we have done for
the past 20 years.
Eunice Kennedy Shriver National Institute of Child Health and Human Development
CFDA Code
865
DUNS Number
068552207
UEI
L6NFUM28LQM5
Project Start Date
01-July-2002
Project End Date
30-April-2028
Budget Start Date
01-May-2024
Budget End Date
30-April-2025
Project Funding Information for 2024
Total Funding
$327,854
Direct Costs
$365,832
Indirect Costs
$25,801
Year
Funding IC
FY Total Cost by IC
2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
$327,854
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5T32HD043010-22
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for 5T32HD043010-22
Patents
No Patents information available for 5T32HD043010-22
Outcomes
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No Outcomes available for 5T32HD043010-22
Clinical Studies
No Clinical Studies information available for 5T32HD043010-22
News and More
Related News Releases
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History
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Similar Projects
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