PROJECT ABSTRACT
This is an application to renew the Infectious Diseases/Basic Microbial Pathogenesis Training Grant from
Washington University. With the advent of generally available antibiotic therapy about 50 years ago, many
physicians and scientists predicted the end of infectious diseases as a major area of health concern.
Subsequent events have proven this prediction wrong, and the past decades have seen the emergence of
many newly identified infectious diseases, including Lyme Disease, erlichiosis, SARS, COVID-19, West Nile
encephalitis, chikungunya, MERS, ebola and HIV. The reemergence of old infectious diseases, such as
malaria and tuberculosis, in more virulent and more antibiotic resistant forms also has increased public
attention on the health problems posed by infectious diseases. It is rare that a week goes by without some
troubling headline concerning new infectious disease outbreaks. Thus, far from gradual disappearance as a
health concern, infectious diseases have emerged as being of increasing importance to the health concerns
of the nation. The emerging antibiotic resistance of current pathogens and the rise of new disease agents
have made clear the necessity of increased fundamental scientific investigation into all aspects of infectious
diseases. The purpose of the Washington University Training Program in Infectious Diseases/Basic Microbial
Pathogenesis is to help fulfill this need by recruiting promising young investigators to this field and training
them in outstanding research programs with preeminent investigators who collaborate across multiple
disciplines (or who function in interdisciplinary teams) to perform infectious disease research. Our Training
Program, which has had NIH support for the past 40 years, integrates faculty from four departments:
Medicine, Pediatrics, Molecular Microbiology and Pathology & Immunology. The program provides training to
M.D., Ph.D., and M.D./Ph.D. postdoctoral fellows, and to Ph.D. and M.D./Ph.D. students, in disciplines
related to pathogenesis and host defense in Infectious Diseases. The laboratories of the program preceptors
use tools of molecular biology, biochemistry, genetics, genomics, immunology, cell biology and translational
medicine. Thus, the program trains young investigators to be able to answer the important questions of
microbial pathogenesis, from studies of basic biology through application to the bedside.
Public Health Relevance Statement
PROJECT NARRATIVE
The alarming antibiotic resistance of current pathogens and the emergence of new disease agents have made
clear the necessity of increased fundamental scientific investigation into all aspects of infectious diseases. The
purpose of the Washington University Training Program in Infectious Diseases/Basic Microbial Pathogenesis is
to help fulfill this need by recruiting promising young investigators to this field and training them in outstanding
research programs with preeminent investigators who collaborate across multiple disciplines to perform
infectious disease research.
National Institute of Allergy and Infectious Diseases
CFDA Code
855
DUNS Number
068552207
UEI
L6NFUM28LQM5
Project Start Date
15-September-1980
Project End Date
30-June-2026
Budget Start Date
01-July-2024
Budget End Date
30-June-2025
Project Funding Information for 2024
Total Funding
$581,385
Direct Costs
$664,738
Indirect Costs
$45,407
Year
Funding IC
FY Total Cost by IC
2024
National Institute of Allergy and Infectious Diseases
$581,385
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5T32AI007172-44
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
No Publications available for 5T32AI007172-44
Patents
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Outcomes
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No Outcomes available for 5T32AI007172-44
Clinical Studies
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News and More
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History
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