Washington University School of Medicine and the affiliated Barnes-Jewish Hospital have a 40-year tradition
of excellence in musculoskeletal research, patient care, education and training. In 2011, the Skeletal Disorders
Training Program (SDTP) was established under the leadership of Dr. Roberto Civitelli, with the purpose of
training the next generation of skeletal investigators, and it was renewed in 2015. This SDTP provides the
educational and mentoring infrastructure of the WU Musculoskeletal Research Center, a partnership between
the Departments of Medicine (Division of Bone and Mineral Diseases) and Orthopaedic Surgery, supported by
a NIAMS-funded P30 award, thus integrating the complementary aims of this T32 and the P30 into a unified
structure. The SDTP offers 3 pre- and 3 post-doctoral positions and has so far enrolled 27 trainees (12
graduate students and 15 post-doctoral fellows). Of these, 5 have progressed to faculty appointments, 5 to
permanent positions in industry; one has been awarded a K99/R00 grant; 5 have received an F-type award.
Together, they have published 104 articles directly linked to this program and received numerous awards and
recognitions. This SDTP offers research training in 5 thematic areas, reflecting the focus and common interests
of the participating faculty: 1) Musculoskeletal Biomechanics; 2) Skeletal Development and Regeneration; 3)
The Skeleton and Other Systems; 4) Skeletal Immunology; 5) Tumor-Skeleton Interactions. Mentors selected
for this SDTP are drawn from 9 academic Departments and Programs at WU. The program is based on 4 training
domains: 1) mentored research training; 2) curriculum coursework; 3) enrichment activities; 4) career
development. The training program builds on the graduate programs administered by the Division of Biology and
Biomedical Sciences and the Department of Biomedical Engineering and leverages the Institute for Translational
and Clinical Sciences and other institutional resources. Specific innovations proposed include,1) development
of non-academic research training opportunities; 2) expansion of training in rigor and reproducibility; 3) addition
of a mentor education plan; 4) enhanced participation of previous trainees and creation of an Alumni Network;
5) new efforts in increasing participation of URM to the program; 6) increased emphasis on career development
training. These new SDTP trained researchers will make the future discoveries in the genetic and molecular
bases of skeletal disorders, and eventually improve the treatment of osteoporosis, inflammatory osteolysis,
osteoarthritis, bone metastasis, and other skeletal disorders that afflict a large proportion of the elderly population.
Public Health Relevance Statement
Skeletal disorders, such as osteoporosis, inflammatory osteolysis, osteoarthritis, skeletal deformities, and
bone metastasis afflict a large proportion of the elderly population. This training program educates and forms
the next generation of scientists and physician-scientists committed to make discoveries on skeletal disorders,
so that a better understanding of the causes of these diseases can be achieved, and the search for new
treatment modalities can progress.
National Institute of Arthritis and Musculoskeletal and Skin Diseases
CFDA Code
846
DUNS Number
068552207
UEI
L6NFUM28LQM5
Project Start Date
01-May-2011
Project End Date
30-April-2027
Budget Start Date
01-May-2024
Budget End Date
30-April-2025
Project Funding Information for 2024
Total Funding
$215,903
Direct Costs
$400,398
Indirect Costs
$26,752
Year
Funding IC
FY Total Cost by IC
2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases
$215,903
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5T32AR060719-13
Publications
Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.
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Patents
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Outcomes
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No Outcomes available for 5T32AR060719-13
Clinical Studies
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