Training OPportunites in Translational Imaging Education and Research (TOP-TIER)
Project Number5T32EB021955-08
Former Number5T32EB021955-05
Contact PI/Project LeaderWOODARD, PAMELA K Other PIs
Awardee OrganizationWASHINGTON UNIVERSITY
Description
Abstract Text
PROJECT SUMMARY
TOP-TIER (Training OPportunities in Translational Imaging Education and Research) is a clinician scientist
post-doctoral training program at Washington University (WU) in St. Louis designed with the purpose of
providing trainees with instruction in the performance of rigorous translational imaging research. The goal
is to prepare resident and fellow trainees for careers as successful independent investigators and to
ultimately become leaders in their field, developing imaging techniques and applications that translate into
human subjects and impact healthcare. Precision Medicine is an approach to disease treatment and
prevention that takes into account individual variability in genes, environment, and lifestyle. Development
of methods of patient-specific biomarker imaging to guide and monitor patient-specific therapies will be
needed to advance Precision Medicine. Moreover, a trained workforce is key to taking advantage of new
developments in machine learning and artificial intelligence which can be applied across disciplines, to
include targeted molecular imaging, photoacoustics, and magnetic resonance imaging (MRI) in terms of
data acquisition, image processing, and diagnosis. Such imaging advances are interdisciplinary with
technology innovations crossing the physical, biological, and data sciences. These studies start with
preclinical mechanistic inquiries using targeted pathology-based imaging in animal disease models, and
then expand into human subjects. Human studies include safety testing and the Food and Drug
Administration’s (FDA) Investigational New Drug (IND) and Device Exemption (IDE) process. The ultimate
goal is to make research innovations widely available to the public and the entire practicing medical
community. Although this “bench-to-bedside” process has been widely acclaimed, there remains a
knowledge gap in the medical imaging research community as to how to take preclinical research into
humans, and how to then take these innovations to the public. Moreover, clinical scientists – residents and
fellows – often lack the understanding to navigate research regulatory requirements as well as the
knowledge base to understand or perform preclinical research that will inform the mechanism of innovation.
In this T32 renewal, we have optimized training to provide supportive Mentoring Teams and cover technical
advances, research rigor, and the practical aspects of grant submission to better prepare future imaging
scientists for the challenges of performing science which impacts healthcare.
Public Health Relevance Statement
PROJECT NARRATIVE
An interdisciplinary approach is required to better prepare future clinician scientists for the challenges and
opportunities of imaging research in Precision Medicine. The TOP-TIER T32 program trains post-doctoral
clinician scientists in the performance of translational imaging research, providing them with the skill set to
transition to independent investigators capable of taking imaging research from bench-to-bedside and
imaging innovation into tomorrow’s healthcare.
National Institute of Biomedical Imaging and Bioengineering
CFDA Code
286
DUNS Number
068552207
UEI
L6NFUM28LQM5
Project Start Date
07-August-2017
Project End Date
31-July-2027
Budget Start Date
01-August-2024
Budget End Date
31-July-2025
Project Funding Information for 2024
Total Funding
$249,428
Direct Costs
$271,092
Indirect Costs
$19,887
Year
Funding IC
FY Total Cost by IC
2024
National Institute of Biomedical Imaging and Bioengineering
$249,428
Year
Funding IC
FY Total Cost by IC
Sub Projects
No Sub Projects information available for 5T32EB021955-08
Publications
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No Publications available for 5T32EB021955-08
Patents
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Outcomes
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No Outcomes available for 5T32EB021955-08
Clinical Studies
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History
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