RePORT ⟩ RePORTER

Skip Navigation Links

Search Results

Project Details

Fluorescence Microscopy

Project Number1ZICES102485-14 NIDB ANNUAL REPORT

Contact PI/Project LeaderTUCKER, CHARLES

Awardee OrganizationNATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

Description

Abstract Text

In meeting the goals and objectives of FMIC, the center continues to: -Service and maintain state-of-the-art equipment for unlimited access by intramural scientists. -Provide investigator training in the use and analysis of fluorescence and optical-based techniques. -Develop and optimize experimental protocols in collaboration with intramural scientists. -Maintain and develop state-of-the-art analysis tools and protocols in collaboration with investigators -Monitor and incorporate emerging fluorescence and optical technologies that will support the mission of NIEHS into FMIC. During this fiscal year, FMIC has collaborated and supported 46 Principle Investigators from 8 branches/laboratories within the NIEHS DIR. Some publications from this FY resulting from work in the center is listed in the bibliography below: Bibliography Busada JT, Peterson KN, Khadka S, Xu X, Oakley RH, Cook DN, Cidlowski JA. Glucocorticoids and Androgens Protect From Gastric Metaplasia by Suppressing Group 2 Innate Lymphoid Cell Activation. Gastroenterology. 2021. Epub 2021/05/11. doi: 10.1053/j.gastro.2021.04.075. PubMed PMID: 33971182. Carstens KE, Lustberg DJ, Shaughnessy E, McCann KE, Alexander GM, Dudek SM. Perineuronal net degradation rescues CA2 plasticity in Rett syndrome model mice. J Clin Invest. 2021. Epub 2021/07/07. doi: 10.1172/jci137221. PubMed PMID: 34228646. Carstens KE, Gloss BR, Alexander GM, Dudek SM. Modified adeno-associated virus targets the bacterial enzyme chondroitinase ABC to select mouse neuronal populations in vivo using the Cre-LoxP system. Eur J Neurosci. 2020. Epub 2020/11/22. doi: 10.1111/ejn.15050. PubMed PMID: 33220084; PMCID: PMC8137719. Chi RA, Wang T, Huang CL, Wu SP, Young SL, Lydon JP, DeMayo FJ. WNK1 regulates uterine homeostasis and its ability to support pregnancy. JCI Insight. 2020;5(22). Epub 2020/10/14. doi: 10.1172/jci.insight.141832. PubMed PMID: 33048843; PMCID: PMC7710275. Damborsky JC, Yakel JL. Regulation of hippocamposeptal input within the medial septum/diagonal band of Broca. Neuropharmacology. 2021;191:108589. Epub 2021/05/03. doi: 10.1016/j.neuropharm.2021.108589. PubMed PMID: 33933476; PMCID: PMC8217288. Foo ACY, Thompson PM, Chen SH, Jadi R, Lupo B, DeRose EF, Arora S, Placentra VC, Premkumar L, Perera L, Pedersen LC, Martin N, Mueller GA. The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism. Proc Natl Acad Sci U S A. 2021;118(11). Epub 2021/03/11. doi: 10.1073/pnas.2019251118. PubMed PMID: 33688047; PMCID: PMC7980415. Kar P, Lin YP, Bhardwaj R, Tucker CJ, Bird GS, Hediger MA, Monico C, Amin N, Parekh AB. The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca(2+) entry. Proc Natl Acad Sci U S A. 2021;118(19). Epub 2021/05/05. doi: 10.1073/pnas.2012908118. PubMed PMID: 33941685; PMCID: PMC8126794. Karcz TP, Whitehead GS, Nakano K, Nakano H, Grimm SA, Williams JG, Deterding LJ, Jacobson KA, Cook DN. UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia. J Clin Invest. 2021;131(7). Epub 2021/04/02. doi: 10.1172/jci140709. PubMed PMID: 33792561; PMCID: PMC8011887. Nacer SA, Letsinger AC, Otto S, DeFilipp JS, Nikolova VD, Riddick NV, Stevanovic KD, Cushman JD, Yakel JL. Loss of 7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior. Brain Struct Funct. 2021;226(2):365-79. Epub 2021/01/06. doi: 10.1007/s00429-020-02179-3. PubMed PMID: 33398432; PMCID: PMC8121181. Nichols CE, House JS, Li H, Ward JM, Wyss A, Williams JG, Deterding LJ, Bradbury JA, Miller L, Zeldin DC, London SJ. Lrp1 Regulation of Pulmonary Function. Follow-Up of Human GWAS in Mice. Am J Respir Cell Mol Biol. 2021;64(3):368-78. Epub 2020/12/09. doi: 10.1165/rcmb.2019-0444OC. PubMed PMID: 33290178; PMCID: PMC7909338. Rai P, Janardhan KS, Meacham J, Madenspacher JH, Lin WC, Karmaus PWF, Martinez J, Li QZ, Yan M, Zeng J, Grinstaff MW, Shirihai OS, Taylor GA, Fessler MB. IRGM1 links mitochondrial quality control to autoimmunity. Nat Immunol. 2021;22(3):312-21. Epub 2021/01/30. doi: 10.1038/s41590-020-00859-0. PubMed PMID: 33510463; PMCID: PMC7906953. Sinha BK, Perera L, Cannon RE. NCX-4040, a Unique Nitric Oxide Donor, Induces Reversal of Drug-Resistance in Both ABCB1- and ABCG2-Expressing Multidrug Human Cancer Cells. Cancers (Basel). 2021;13(7). Epub 2021/05/01. doi: 10.3390/cancers13071680. PubMed PMID: 33918289; PMCID: PMC8038154. Squires KE, Gerber KJ, Tillman MC, Lustberg DJ, Montaez-Miranda C, Zhao M, Ramineni S, Scharer CD, Saha RN, Shu FJ, Schroeder JP, Ortlund EA, Weinshenker D, Dudek SM, Hepler JR. Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons. J Biol Chem. 2020;296:100024. Epub 2021/01/08. doi: 10.1074/jbc.RA120.016009. PubMed PMID: 33410399; PMCID: PMC7949046. Yan Y, Liu J, Lawrence A, Dykstra MJ, Fannin R, Gerrish K, Tucker CJ, Scappini E, Dixon D. Prolonged cadmium exposure alters benign uterine fibroid cell behavior, extracellular matrix components, and TGFB signaling. Faseb j. 2021;35(8):e21738. Epub 2021/07/11. doi: 10.1096/fj.202100354R. PubMed PMID: 34245615. Yu L, Liu J, Yan Y, Burwell A, Castro L, Shi M, Dixon D. "Metalloestrogenic" effects of cadmium downstream of G protein-coupled estrogen receptor and mitogen-activated protein kinase pathways in human uterine fibroid cells. Arch Toxicol. 2021;95(6):1995-2006. Epub 2021/04/06. doi: 10.1007/s00204-021-03033-z. PubMed PMID: 33818655; PMCID: PMC8166678.

Public Health Relevance Statement

Data not available.

NIH Spending Category

Neurosciences

Project Terms

ABCB1 geneABCG2 geneAllergensAndrogensAntiviral AgentsAutoimmunityBenignBibliographyBirdsBrainCadmiumCellsChondroitin ABC LyaseCognitiveCollaborationsComplexCouplesCulicidaeDependovirusDiagonal Band of BrocaDrug resistanceEnsureEnzymesEosinophiliaEquipmentExtracellular MatrixFluorescenceFluorescence MicroscopyGPER geneGPR105 receptorGastric MetaplasiaGastroenterologyGlucocorticoidsGlucoseGoalsHippocampus (Brain)HomeostasisHumanHuman GeneticsImpairmentKnowledgeLaboratoriesLinkLipidsLondonLymphoid CellMalignant NeoplasmsMedialMissionMitochondriaMitogen-Activated Protein KinasesMonitorMusNational Institute of Environmental Health SciencesNeurogliaNeuronsNeuropharmacologyNicotinic ReceptorsNitric Oxide DonorsNuclearOpticsPathway interactionsPopulationPregnancyPropertyProteinsProtocols documentationPubMedPublicationsQuality ControlRadialRegulationResearchResearch PersonnelRett SyndromeScientistServicesSignal TransductionSocial BehaviorTGFB1 geneTechniquesTechnologyTrainingUterine FibroidsUterusWorkbasecancer cellcell behaviorcookingfollow-upgenetic variantgenome wide association studyin vivoinsightinvestigator trainingmeetingsmicroscopic imagingmouse modelpulmonary functionrecombinase-mediated cassette exchangesexskillstoolward

Details

Contact PI/ Project Leader

Name

TUCKER, CHARLES

Title

Contact

Other PIs

Not Applicable

Program Official

Name

Contact

Email not available

Organization

Name

NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

City

Country

UNITED STATES

Department Type

Unavailable

Organization Type

Unavailable

State Code

Congressional District

Other Information

Opportunity Number

Study Section

Fiscal Year

2021

Award Notice Date

Administering Institutes or Centers

National Institute of Environmental Health Sciences

CFDA Code

DUNS Number

UEI

Project Start Date

Project End Date

Budget Start Date

Budget End Date

Project Funding Information for 2021

Total Funding

$1,434,389

Direct Costs

Indirect Costs

Year	Funding IC	FY Total Cost by IC
2021	National Institute of Environmental Health Sciences	$1,434,389

NIH Categorical SpendingClick here for more information on NIH Categorical Spending

Funding IC	FY Total Cost by IC	NIH Spending Category
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES	$1,434,389	Neurosciences

Sub Projects

No Sub Projects information available for 1ZICES102485-14

Publications

Publications are associated with projects, but cannot be identified with any particular year of the project or fiscal year of funding. This is due to the continuous and cumulative nature of knowledge generation across the life of a project and the sometimes long and variable publishing timeline. Similarly, for multi-component projects, publications are associated with the parent core project and not with individual sub-projects.

No Publications available for 1ZICES102485-14

Patents

No Patents information available for 1ZICES102485-14

Outcomes

The Project Outcomes shown here are displayed verbatim as submitted by the Principal Investigator (PI) for this award. Any opinions, findings, and conclusions or recommendations expressed are those of the PI and do not necessarily reflect the views of the National Institutes of Health. NIH has not endorsed the content below.

No Outcomes available for 1ZICES102485-14

Clinical Studies

No Clinical Studies information available for 1ZICES102485-14

News and More

Section Menu